LOCUS       HSU22029     2282 bp    mRNA            PRI       01-JAN-1997
DEFINITION  Human cytochrome P450 (CYP2A7) mRNA, complete cds.
ACCESSION   U22029
NID         g1008465
KEYWORDS    .
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2282)
  AUTHORS   Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
            Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
            Idle,J.R. et,al.
  TITLE     A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
            human CYP2A genes and identification of variant CYP2A6 alleles
  JOURNAL   Am. J. Hum. Genet. 57 (3), 651-660 (1995)
  MEDLINE   95397851
REFERENCE   2  (bases 1 to 2282)
  AUTHORS   Fernandez-Salguero,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-MAR-1995) Pedro Fernandez-Salguero, National
            Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20894, USA
FEATURES             Location/Qualifiers
     source          1..2282
                     /organism="Homo sapiens"
                     /strain="490A"
                     /db_xref="taxon:9606"
     gene            544..2028
                     /gene="CYP2A7"
     CDS             544..2028
                     /gene="CYP2A7"
                     /codon_start=1
                     /product="cytochrome P450"
                     /db_xref="PID:g1008466"
                     /translation="MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIG
                     NYLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRG
                     EQATFEWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAI
                     RSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQ
                     LYEMFSSLMKHLPGPQQQAFKLLLGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQ
                     EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV
                     IGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVF
                     PMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKRDAFVPFSIRKRNCFGEGLARMELF
                     LFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR"
     3'UTR           2029..2282
BASE COUNT      519 a    654 c    613 g    496 t
ORIGIN
        1 ccctgggtct tcctagcccc gaggctttca agtccatatt cctggagtcc cccctcctga
       61 gacccttaac cctgcatcct ccgcaacaga agacccccag atgcacagcc acacttccat
      121 ctcaccctaa taaaacccag acctttggat tcctctccct tggaatgccc aaatccacaa
      181 ctttggggtt gcattctcac tccaagatcc caaatccaaa gcccaagtgc tcccctatgc
      241 aaatattccc aactcctttg ttctacagct tatctgttgc ccgctcctaa atccacagcc
      301 ctggggcacc cctcctgagg taccacagat ttagtcggga ggtaccctct ctgttcagct
      361 tccctggggt ccccctcctc ctcctttgct ggttgtgtcc aaagctaggt ggggttcacg
      421 gagaggatgt agttgggagg tgaaatgagg tgattttata accagccaaa gtccacccct
      481 ttttttcagg cagtataaag gcaaaccacc ccacccatca ccatctgtca tctcactacc
      541 accatgctgg cctcaggact gcttctggtg gccttgctgg cctgcctgac tgtgatggtc
      601 ttgatgtctg tctggcagca gaggaagagc agggggaagc tgcctccggg acccacccca
      661 ctgcccttca ttggaaacta cctccagctg aacacagagc acatatgtga ctccatcatg
      721 aagttcagtg agtgctatgg ccccgtgttc accattcact tggggccccg gcgggtcgtg
      781 gtgctgtgtg gacatgatgc cgtcagggag gctctggtgg accaggctga ggagttcagc
      841 gggcgaggcg agcaagccac cttcgaatgg gtcttcaaag gctatggcgt ggcgttcagc
      901 aacggggagc gcgccaagca gctcctgcgc tttgccatcg ccaccctgag ggacttcggg
      961 gtgggcaagc gaggcatcga ggagcgcatc caggaggagt cgggcttcct catcgaggcc
     1021 atccggagca cgcacggcgc caatatcgat cccaccttct tcctgagccg cacagtctcc
     1081 aatgtcatca gctccattgt ctttggggac cgctttgact atgaggacaa agagttcctg
     1141 tcactgctga gcatgatgct aggaatcttc cagttcacgt caacctccac ggggcagctc
     1201 tatgagatgt tctcttcgct gatgaaacac ctgccaggac cacagcaaca ggcctttaag
     1261 ttgctgctag ggctggagga cttcatagcc aagaaggtgg agcacaacca gcgcacgctg
     1321 gatcccaatt ccccacagga cttcatcgac tcctttctca tccacatgca ggaggaggag
     1381 aagaacccca acacggagtt ctacttgaag aacctgatga tgagcacgtt gaacctcttc
     1441 attgcaggca ccgagacggt cagcaccacc ctgcgctatg gcttcttgct gctcatgaag
     1501 cacccagagg tggaggccaa ggtccatgag gagattgaca gagtgatcgg caagaaccgg
     1561 cagcccaagt ttgaggaccg gaccaagatg ccctacatgg aggcagtgat ccacgagatc
     1621 caaagatttg gagacgtgat ccccatgagt ttggcccgca gggtcaaaaa ggacaccaag
     1681 tttcgggatt ttttcctccc taagggcaca gaagtgttcc ctatgctggg ctccgtgctg
     1741 agagacctca ggttcttctc caacccccgg gacttcaatc cccagcactt cctgggtgag
     1801 aaggggcagt ttaagaagcg tgatgctttt gtgcccttct ccatcagaaa gcggaactgt
     1861 ttcggagaag gcctggccag aatggagctc tttctcttct tcaccaccgt catgcagaac
     1921 ttccgcctca agtcctccca gtcacctaag gacattgacg tgtcccccaa acacgtggtc
     1981 tttgccacga tcccacgaaa ctacaccatg agcttcctgc cccgctgatc gagggctgtg
     2041 ccggtgaagg tctggtgggc ggggccaggg aaaggcgggg tcagggcggg gttcgcggaa
     2101 gaggcgggta taagaatggg gggaagatgc gggaaaggaa ggggcgtggt ggctagaggg
     2161 aagagaagaa acagaagcgg ctcagttcac cttgataagg tgcttccgag ctgggatgag
     2221 aggaagggaa accttacatt atgctatgaa gagtagtaat aatagcagct cttatttcct
     2281 ga