Chapter 6: Proteomics

Section 6.1 Introduction

• What do all these proteins do?
• Which proteins are needed in different conditions?
• Can you live without some proteins?

6.1 How do you know if you have sampled enough cells?

 

Section 6.2 Protein 3D Structures

• Does a protein’s shape reveal its function?
• Can we use structures to develop better drugs?
• Can one protein kill you?

Section 6.3 Protein Interaction Networks

• Which proteins interact with each other?
• How can we measure protein interactions?
• Is it possible to understand proteome-wide interactions?

6.2 Is Sup35 a central protein in the network?

 

Section 6.4 Measuring Proteins

• How do we know which proteins are present?
• What proteins do our white blood cells need to kill a pathogen?
• How much of each protein is present?
• Can we make protein chips?
• Are all cells equal?
• What does a proteome produce?