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Structure of CD1b

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Figure 1: Cd1b In Complex With Phophatidylinositol. MMDB: 20045 PDB: 1GZQ

Gadola, S.D., Zaccai, N.R., Harlos, K., Shepherd, D., Castro-Palomino, J.C., Ritter, G., Schmidt, R.R., Jones, E.Y., Cerundolo, V. 2002. "Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains." Nat Immunol 3:721-726 (abstract)

Figure 2: Cd1b In Complex With Gm2 Ganglioside MMDB: 20044 PDB: 1GZP

Gadola, S.D., Zaccai, N.R., Harlos, K., Shepherd, D., Castro-Palomino, J.C., Ritter, G., Schmidt, R.R., Jones, E.Y., Cerundolo, V. 2002. "Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains." Nat Immunol 3:721-726 (abstract)

Note the similarities in the above molecule to the MHC Class I molecule below. Both molecules contain an alpha chain, a b2-microglobulin, and a bound ligand.

Figure 3: MHC Class I molecule with bound protein. Obtained from http://bio.davidson.edu/courses/Immunology/chime/mhc/2FRMCONT.HTM.

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