5 2833362 207 aa 01-NOV-1997
DEFINITION CELLULAR TUMOR ANTIGEN P53.
ACCESSION 2833362
PID g2833362
DBSOURCE SWISS-PROT: locus P53_EQUAS, accession Q29480
class: standard.
created: Nov 1, 1997.
sequence updated: Nov 1, 1997.
annotation updated: Nov 1, 1997.
xrefs: gi: 1020152, gi: 1020153
xrefs (non-sequence databases): PROSITE PS00348
KEYWORDS ANTI-ONCOGENE; DNA-BINDING; TRANSCRIPTION REGULATION; ACTIVATOR;
NUCLEAR PROTEIN; PHOSPHORYLATION; APOPTOSIS.
SOURCE Equus asinus.
ORGANISM Equus asinus
Eukaryotae; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Perissodactyla; Equidae; Equus.
REFERENCE 1 (residues 1 to 207)
AUTHORS Nasir,L. and Reid,S.W.
TITLE Nucleotide sequence of exons 5 to 9 of the p53 tumour suppressor
gene of the donkey (Equus asinus)
JOURNAL DNA Seq. 6 (1), 61-63 (1995)
MEDLINE 96342529
REMARK SEQUENCE FROM N.A.
COMMENT [FUNCTION] ACT AS A TUMOR SUPPRESSOR IN MANY TUMOR TYPES. INDUCES
GROWTH ARREST OR APOPTOSIS DEPENDING ON THE PHYSIOLOGICAL
CIRCUMSTANCES OR CELL TYPE, BUT BOTH ACTIVITIES ARE INVOLVED IN
TUMOR SUPPRESSION. IT ACTS IN CELL CYCLE REGULATION, IT IS A
TRANS-ACTIVATOR THAT ACTS TO NEGATIVELY REGULATE CELLULAR DIVISION
BY CONTROLLING A SET OF GENES REQUIRED FOR THIS PROCESS. ONE OF THE
GENES ACTIVATED IS AN INHIBITOR OF CYCLIN-DEPENDENT KINASES.
APOPTOSIS INDUCTION SEEMS TO BE MEDIATED EITHER BY STIMULATION OF
BAX AND FAS ANTIGEN EXPRESSION, OR BY REPRESSION OF BCL-2
EXPRESSION (BY SIMILARITY).
[SUBCELLULAR LOCATION] NUCLEAR.
[DISEASE] P53 IS FOUND IN INCREASED AMOUNTS IN A WIDE VARIETY OF
TRANSFORMED CELLS. P53 IS FREQUENTLY MUTATED OR INACTIVATED IN MANY
TYPES OF CANCER.
[SIMILARITY] STRONG, TO P53 IN OTHER HIGHER EUKARYOTES.
FEATURES Location/Qualifiers
source 1..207
/organism="Equus asinus"
/db_xref="taxon:9793"
1..207
Protein <1..>207
/product="CELLULAR TUMOR ANTIGEN P53"
Region 187..199
/note="NUCLEAR LOCALIZATION SIGNAL."
/region_name="Domain"
ORIGIN
1 yspalnkmfc qlaktcpvyl rissppppgt rvramaiykk sefmtevvrr cphhercsds
61 sdglappqhl irvegnlrae ylddrntlrh svvvpyeppe vgsdcttihy nfmcnsscmg
121 gmnrrpilti itledssgnl lgrnsfevrv cacpgrdrrt eeenfrkkee pcpeppprst
181 krvlssntss sppqkedpld geyftlh
//

the above report in format