1
LOCUS 129371 390 aa 01-NOV-1997
DEFINITION CELLULAR TUMOR ANTIGEN P53.
ACCESSION 129371
PID g129371
DBSOURCE SWISS-PROT: locus P53_MOUSE, accession P02340
class: standard.
created: Jul 21, 1986.
sequence updated: Nov 1, 1990.
annotation updated: Nov 1, 1997.
xrefs: gi: 871420, gi: 871421, gi: 200204, gi: 200205, gi: 53575,
gi: 53576, gi: 53570, gi: 53571, gi: 200198, gi: 200199, gi:
200200, gi: 200201, gi: 200202, gi: 200203, gi: 243254, gi: 243255,
gi: 2144761, gi: 90366, gi: 481533
xrefs (non-sequence databases): HSSP P04637, TRANSFAC T01806, MGD
MGI:98834, PROSITE PS00348
KEYWORDS ANTI-ONCOGENE; DNA-BINDING; TRANSCRIPTION REGULATION; ACTIVATOR;
NUCLEAR PROTEIN; PHOSPHORYLATION; APOPTOSIS; DISEASE MUTATION.
SOURCE house mouse.
ORGANISM Mus musculus
Eukaryotae; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Rodentia; Sciurognathi; Muridae; Murinae; Mus.
REFERENCE 1 (residues 1 to 390)
AUTHORS Bienz,B., Zakut-Houri,R., Givol,D. and Oren,M.
TITLE Analysis of the gene coding for the murine cellular tumour antigen
p53
JOURNAL EMBO J. 3 (9), 2179-2183 (1984)
MEDLINE 85027173
REMARK SEQUENCE FROM N.A.
REFERENCE 2 (residues 1 to 390)
AUTHORS Zakut-Houri,R., Oren,M., Bienz,B., Lavie,V., Hazum,S. and Givol,D.
TITLE A single gene and a pseudogene for the cellular tumour antigen p53
JOURNAL Nature 306 (5943), 594-597 (1983)
MEDLINE 84068204
REMARK SEQUENCE FROM N.A.
REFERENCE 3 (residues 1 to 390)
AUTHORS Jenkins,J.R., Rudge,K., Redmond,S. and Wade-Evans,A.
TITLE Cloning and expression analysis of full length mouse cDNA sequences
encoding the transformation associated protein p53
JOURNAL Nucleic Acids Res. 12 (14), 5609-5626 (1984)
MEDLINE 84272240
REMARK SEQUENCE FROM N.A.
REFERENCE 4 (residues 1 to 390)
AUTHORS Arai,N., Nomura,D., Yokota,K., Wolf,D., Brill,E., Shohat,O. and
Rotter,V.
TITLE Immunologically distinct p53 molecules generated by alternative
splicing
JOURNAL Mol. Cell. Biol. 6 (9), 3232-3239 (1986)
MEDLINE 87064640
REMARK SEQUENCE FROM N.A. (CLONES PCD53; P53-M11 AND P53-M8).
REFERENCE 5 (residues 1 to 390)
AUTHORS Burns,P.A., Kemp,C.J., Gannon,J.V., Lane,D.P., Bremner,R. and
Balmain,A.
TITLE Loss of heterozygosity and mutational alterations of the p53 gene
in skin tumours of interspecific hybrid mice
JOURNAL Oncogene 6 (12), 2363-2369 (1991)
MEDLINE 92115342
REMARK SEQUENCE OF 222-258 FROM N.A.
REFERENCE 6 (residues 1 to 390)
AUTHORS Samad,A., Anderson,C.W. and Carroll,R.B.
TITLE Mapping of phosphomonoester and apparent phosphodiester bonds of
the oncogene product p53 from simian virus 40-transformed 3T3 cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (4), 897-901 (1986)
MEDLINE 86149247
REMARK PHOSPHORYLATION SITES.
REFERENCE 7 (residues 1 to 390)
AUTHORS Meek,D.W., Simon,S., Kikkawa,U. and Eckhart,W.
TITLE The p53 tumour suppressor protein is phosphorylated at serine 389
by casein kinase II
JOURNAL EMBO J. 9 (10), 3253-3260 (1990)
MEDLINE 91006019
REMARK PHOSPHORYLATION SITES.
COMMENT [FUNCTION] ACT AS A TUMOR SUPPRESSOR IN MANY TUMOR TYPES. INDUCES
GROWTH ARREST OR APOPTOSIS DEPENDING ON THE PHYSIOLOGICAL
CIRCUMSTANCES OR CELL TYPE, BUT BOTH ACTIVITIES ARE INVOLVED IN
TUMOR SUPPRESSION. IT ACTS IN CELL CYCLE REGULATION, IT IS A
TRANS-ACTIVATOR THAT ACTS TO NEGATIVELY REGULATE CELLULAR DIVISION
BY CONTROLLING A SET OF GENES REQUIRED FOR THIS PROCESS. ONE OF THE
GENES ACTIVATED IS AN INHIBITOR OF CYCLIN-DEPENDENT KINASES.
APOPTOSIS INDUCTION SEEMS TO BE MEDIATED EITHER BY STIMULATION OF
BAX AND FAS ANTIGEN EXPRESSION, OR BY REPRESSION OF BCL-2
EXPRESSION.
[SUBCELLULAR LOCATION] NUCLEAR.
[DISEASE] P53 IS FOUND IN INCREASED AMOUNTS IN A WIDE VARIETY OF
TRANSFORMED CELLS. P53 IS FREQUENTLY MUTATED OR INACTIVATED IN MANY
TYPES OF CANCER.
[SIMILARITY] STRONG, TO P53 IN OTHER HIGHER EUKARYOTES.
FEATURES Location/Qualifiers
source 1..390
/organism="Mus musculus"
/db_xref="taxon:10090"
1..390
Region 1..75
/note="ASP/GLU-RICH (ACIDIC)."
/region_name="Domain"
Protein 1..390
/product="CELLULAR TUMOR ANTIGEN P53"
Region 48
/note="Q -> R (IN REF. 3)."
/region_name="Conflict"
Region 76..150
/note="HYDROPHOBIC."
/region_name="Domain"
Region 79..81
/note="PVA -> QW (IN REF. 3)."
/region_name="Conflict"
Region 135
/note="A -> V (CAN COOPERATE WITH AN ACTIVATED RAS TO
TRANSFORM FIBROBLASTS)."
/region_name="Variant"
Region 168
/note="E -> G (IN CLONE P53-M11)."
/region_name="Variant"
Region 276..390
/note="HIGHLY BASIC AND MAY BE INVOLVED IN INTERACTION
WITH DNA."
/region_name="Domain"
Region 308..320
/note="NUCLEAR LOCALIZATION SIGNAL."
/region_name="Domain"
Site 312
/site_type="phosphorylation"
Site 389
/note="(BY CK2)."
/site_type="phosphorylation"
ORIGIN
1 mtameesqsd islelplsqe tfsglwkllp pedilpsphc mddlllpqdv eeffegpsea
61 lrvsgapaaq dpvtetpgpv apapatpwpl ssfvpsqkty qgnygfhlgf lqsgtaksvm
121 ctyspplnkl fcqlaktcpv qlwvsatppa gsrvramaiy kksqhmtevv rrcphhercs
181 dgdglappqh lirvegnlyp eyledrqtfr hsvvvpyepp eagseyttih ykymcnsscm
241 ggmnrrpilt iitledssgn llgrdsfevr vcacpgrdrr teeenfrkke vlcpelppgs
301 akralptcts asppqkkkpl dgeyftlkir grkrfemfre lnealelkda hateesgdsr
361 ahssylktkk gqstsrhkkt mvkkvgpdsd
//





the above report in format