LOCUS HSMK16A 2658 bp RNA PRI 16-NOV-1993

DEFINITION H. sapiens hexokinase I (MK-16).

ACCESSION X66957 S40535 NID g311377

KEYWORDS hexokinase; hexokinase type I.

SOURCE human.

ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.

REFERENCE 1 (bases 1 to 2658)

AUTHORS Magnani,M., Bianchi,M., Casabianca,A., Stocchi,V., Daniele,A., Altruda,F., Ferrone,M. and Silengo,L.

TITLE A recombinant human 'mini'-hexokinase is catalytically active and regulated by hexose 6-phosphates

JOURNAL Biochem. J. 285 (Pt 1), 193-199 (1992)

MEDLINE 92344570 REFERENCE 2 (bases 1 to 2658)

AUTHORS Magnani,M.

TITLE Direct Submission

JOURNAL Submitted (04-SEP-1992) M. Magnani, Inst di Chimica Biologica G Fornaini, Univ degli Sudi di Urbino, Via Saffi 2, 61029 Urbino,

ITALY FEATURES Location/Qualifiers source 1..2658 /organism="Homo sapiens" /db_xref="taxon:9606" /tissue_type="placenta" /clone_lib="cDNA from placenta" /clone="HK-16" /chromosome="10" CDS <1..1896 /EC_number="2.7.1.1" /codon_start=1 /product="hexokinase type 1" /db_xref="PID:g34670" /db_xref="SWISS-PROT:P19367"

/translation="NPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLT RGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAA TLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSE SGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTH NNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAI PIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIV GTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVNEYSLNA GKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETMKTRGIFETKFLSQIESDR LALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLD RLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVR LRTEASS"

BASE COUNT 630 a 682 c 767 g 579 t

ORIGIN 1 aaccctggaa aacagctgtt tgagaagatg gtcagtggca tgtacttggg agagctggtt 61 cgactgatcc tagtcaagat ggccaaggag ggcctcttat ttgaagggcg gatcaccccg 121 gagctgctca cccgagggaa gtttaacacc agtgatgtgt cagccatcga aaagaataag 181 gaaggcctcc acaatgccaa agaaatcctg acccgcctgg gagtggagcc gtccgatgat 241 gactgtgtct cagtccagca cgtttgcacc attgtctcat ttcgctcagc caacttggtg 301 gctgccacac tgggcgccat cttgaaccgc ctgcgtgata acaagggcac acccaggctg 361 cggaccacgg ttggtgtcga cggatctctt tacaagacgc acccacagta ttcccggcgt 421 ttccacaaga ctctaaggcg cttggtgcca gactccgatg tgcgcttcct cctctcggag 481 agtggcagcg gcaagggggc tgccatggtg acggcggtgg cctaccgctt ggccgagcag 541 caccggcaga tagaggagac cctggctcat ttccacctca ccaaagacat gctgctggag 601 gtgaagaaga ggatgcgggc cgagatggag ctggggctga ggaagcagac gcacaacaat 661 gccgtggtta agatgctgcc ctccttcgtc cggagaactc ccgacgggac cgagaatggt 721 gacttcttgg ccctggatct tggaggaacc aatttccgtg tgctgctggt gaaaatccgt 781 agtgggaaaa agagaacggt ggaaatgcac aacaagatct acgccattcc tattgaaatc 841 atgcagggca ctggggaaga gctgtttgat cacattgtct cctgcatctc tgacttcttg 901 gactacatgg ggatcaaagg ccccaggatg cctctgggct tcacgttctc atttccctgc 961 cagcagacga gtctggacgc gggaatcttg atcacgtgga caaagggttt taaggcaaca 1021 gactgcgtgg gccacgatgt agtcacctta ctaagggatg cgataaaaag gagagaggaa 1081 tttgacctgg acgtggtggc tgtggtcaac gacacagtgg gcaccatgat gacctgtgct 1141 tatgaggagc ccacctgtga ggttggactc attgttggga ccggcagcaa tgcctgctac 1201 atggaggaga tgaagaacgt ggagatggtg gagggggacc aggggcagat gtgcatcaac 1261 atggagtggg gggcctttgg ggacaacggg tgtctggatg atatcaggac acactacgac 1321 agactggtga acgaatattc cctaaatgct gggaaacaaa ggtatgagaa gatgatcagt 1381 ggtatgtacc tgggtgaaat cgtccgcaac atcttaatcg acttcaccaa gaagggattc 1441 ctcttccgag ggcagatctc tgagacgatg aagacccggg gcatctttga gaccaagttt 1501 ctctctcaga tcgagagtga ccgattagca ctgctccagg tccgggctat cctccagcag 1561 ctaggtctga atagcacctg cgatgacagt atcctcgtca agacagtgtg cggggtggtg 1621 tccaggaggg ccgcacagct gtgtggcgca ggcatggctg cggttgtgga taagatccgc 1681 gagaacagag gactggaccg tctgaatgtg actgtgggag tggacgggac actctacaag 1741 cttcatccac acttctccag aatcatgcac cagacggtga aggaactgtc accaaaatgt 1801 aacgtgtcct tcctcctgtc tgaggatggc agcggcaagg gggccgccct catcacggcc 1861 gtgggcgtgc ggttacgcac agaggcaagc agctaagagt ccgggatccc cagcctactg 1921 cctctccagc acttctctct tcaagcggcg accccctacc ctcccagcga gttgcgctgg 1981 gagacgctgg cgccagggcc tgccggcgcg ggggaggaaa gcaaaatcca actaatggta 2041 tatattgtag ggtacagaat agagcgtgtg ctgttgataa tatctctcac ccggatcctc 2101 ctcacttgcc ctgccacttt gcatggtttg attttgacct ggtcccccac gtgtgaagtg 2161 tagtggcatc catttctaat gtatgcattc atccaacaga gttatttatt ggctggagat 2221 ggaaaatcac accacctgac aggccttctg ggcctccaaa gcccatcctt ggggttcccc 2281 ctccctgtgt gaaatgtatt atcaccagca gacactgccg ggcctccctc ccgggggcac 2341 tgcctgaagg cgagtgtggg catagcatta gctgcttcct cccctcctgg cacccactgt 2401 ggcctggcat cgcatcgtgg tgtgtcaatg ccacaaaatc gtgtgtccgt ggaaccagtc 2461 ctagccgcgt gtgacagtct tgcattctgt ttgtctcgtg gggggaggtg gacagtcctg 2521 cggaaatgtg tcttgtcttc catttggata aaaggaacca accaacaaac aatgccatca 2581 ctggaatttc ccaccgcttt gtgagccgtg tcgtatgacc tagtaaactt tgtaccaatt 2641 caaaaaaaaa aaaaaaaa