This web page was produced by Zack Perfect as an assignment for an undergraduate course at Davidson College
Below are chime images of Isocitrate Dehydrogenase in E. Coli. Although we isolated IDH from Saccharomyces cerevisiae the structures are very similar and provide insight into their functional significance in the yeast we are studying. To view the images download the Chime plug-in (viewed in the Netscape browser). All the credit to the people responsible for these wonderful depictions are found in the links, respectively.
1. Isocitrate Dehydrogenase S113e Mutant Complexed With Isopropylmalate, Nadp+ And Magnesium
http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?form=6&db=t&Dopt=s&uid=15458
2. Crystal Structure Of K230m Isocitrate Dehydrogenase In Complex With Alpha- Ketoglutarate
http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?form=6&db=t&Dopt=s&uid=10850
3. Low Temperature Structure Of Wild-Type Idh Complexed With Mg-Isocitrate
http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?form=6&db=t&Dopt=s&uid=11279
If the plug-in isn't working, download Rasmol, download the files below, open Rasmol and open the files via the program.
1. Isocitrate Dehydrogenase S113e Mutant Complexed With Isopropylmalate, Nadp+ And Magnesium
2. Crystal Structure Of K230m Isocitrate Dehydrogenase In Complex With Alpha- Ketoglutarate
3. Low Temperature Structure Of Wild-Type Idh Complexed With Mg-Isocitrate