Strongylocentrotus purpuratus Genes in Development:
myb family of transcription factors
SpMyb
Function
SpMyb encodes a transcription factor, which is a member of Myb family.
It is a single copy gene.
SpMyb acts as intramodular negative spatial regulator of the CyIIIa actin gene
(Coffman et al., 1997).
Protein
SpMyb is an approximately 77 kDa protein (Boyle et al., 1986).
The SpMyb DNA-binding
domain contains
three tandem repeats that form the multiple helix-turn-helix
motifs
(Aziz et al., 1995; Miglarese et al., 1996).
GenBank: 2072499
SpMyb protein is expressed in blastula-stage embryos.
Whole mount in situ hybridization was employed to vizualize the distribution of SpMyb transcripts
in prism-stage embryos.
At this stage SpMyb transcripts appear to be largely localized to the
oral ectoderm, mesenchyme and endoderm.
SpMyb is therefore present in regions where it is required
to repress CyIIIa transcription (oral ectoderm and mesenchyme),
and in other regions as well (endoderm) (Coffman et al., 1997).
Gene Networks Database![[Previous]](arrow-1.gif){kind=icon}
UrchiNet![[Up]](arrow-3.gif){kind=icon}
Search the GeNet