Breast Cancer Evaluated with DNA Microarrays


Cluster 84 Samples Using 1754 Genes

Signature Genes

Endothelial cells
Stromal/Fibroblasts
Breast Basal Epithelial
B-Cells
Adipose cells
Macrophage
T-cells
Breast Luminal Epithelial

No Apparent Pattern of Clustering

Cell Lines
 
Patient Biopsies
 
Before/After Samples Clustered
1o Tumor/Node Pair
Normal Breast

 


Intrensic Genes Used to Cluster Same Samples

Luminal Epi./ ER Erb-B2 Overexpression Basal Epi./ Keratins 5, 17 Basal Epithelial  

 

Intrensic Genes-Clustered Samples

Basal-like
Erb-B2+
Normal Breast
Luminal epithelial/ ER+

 

(all figures with permission of Pat Brown)


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