LOCUS 1703056 1131 aa 01-OCT-1996

DEFINITION ACTIVATOR 1 140 KD SUBUNIT (REPLICATION FACTOR C LARGE SUBUNIT) (A1 140 KD SUBUNIT) (RF-C 140 KD SUBUNIT) (ACTIVATOR 1 LARGE SUBUNIT) (A1-P145) (DIFFERENTIATION SPECIFIC ELEMENT BINDING PROTEIN) (ISRE-BINDING PROTEIN).

ACCESSION 1703056 PID g1703056 DB

SOURCE SWISS-PROT: locus AC15_MOUSE, accession P35601 class: standard. created: Jun 1, 1994. sequence updated: Oct 1, 1996. annotation updated: Oct 1, 1996. xrefs: gi: 405111, gi: 405112, gi: 457741, gi: 457742, gi: 1022775, gi: 1022776, gi: 460931, gi: 460932, gi: 555971, gi: 555972 xrefs (non-sequence databases): MGD MGI:97891

KEYWORDS DNA REPLICATION; ATP-BINDING; TRANSCRIPTION REGULATION; DNA-BINDING; ACTIVATOR; NUCLEAR PROTEIN.

SOURCE house mouse.

ORGANISM Mus musculus Eukaryotae; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.

REFERENCE 1 (residues 1 to 1131)

AUTHORS Burbelo,P.D., Utani,A., Pan,Z.Q. and Yamada,Y.

TITLE Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases

JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (24), 11543-11547 (1993) MEDLINE 94089669

REMARK SEQUENCE FROM N.A. STRAIN=BALB/C REFERENCE 2 (residues 1 to 1131)

AUTHORS Luckow,B., Bunz,F., Stillman,B., Lichter,P. and Schutz,G.

TITLE Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans

JOURNAL Mol. Cell. Biol. 14 (3), 1626-1634 (1994) MEDLINE 94158835

REMARK SEQUENCE FROM N.A. TISSUE=LIVER REFERENCE 3 (residues 1 to 1131) AUTHORS MCGEHEE HABENER,J.F. JOURNAL MOL. ENDOCRINOL. 9, 487-501 (1995) MEDLINE 95388065 REMARK SEQUENCE FROM N.A. STRAIN=SWISS REFERENCE 4 (residues 1 to 1131)

AUTHORS HAQUE,S.J.

TITLE Direct Submission JOURNAL Submitted (??-FEB-1994) TO EMBL/GENBANK/DDBJ DATA BANKS REMARK SEQUENCE FROM N.A. REFERENCE 5 (residues 1 to 1131)

AUTHORS LOSSIE,A.C., HAUGEN,B.H., WOOD,W.M., CAMPER,S.A. and GORDON,D.F.

TITLE Direct Submission JOURNAL Submitted (??-OCT-1994) TO EMBL/GENBANK/DDBJ DATA BANKS REMARK SEQUENCE OF 1-565 FROM N.A. STRAIN=LAF1 REFERENCE 6 (residues 1 to 1131)

AUTHORS HAQUE,S.J., KUMAR,A., FISCHER,T., RUTHERFORD,M.N. and WILLIAMS,B.R.

JOURNAL J. INTERFERON RES. 10, 31-31 (1990) MEDLINE 90229765 REMARK SEQUENCE OF 354-528 FROM N.A. COMMENT [FUNCTION] THE ELONGATION OF PRIMED DNA TEMPLATES BY DNA POLYMERASE DELTA AND EPSILON REQUIRES THE ACTION OF THE ACCESSORY PROTEINS PCNA AND ACTIVATOR 1. THE 140 SUBUNIT BINDS TO THE PRIMER-TEMPLATE JUNCTION. [SUBUNIT] HETEROPENTAMER OF SUBUNITS OF 140/145, 40, 38, 37, AND 36.5 KD THAT FORMS A COMPLEX WITH PCNA IN THE PRESENCE OF ATP. [SUBCELLULAR LOCATION] NUCLEAR. [SIMILARITY] LOCAL, TO BACTERIAL DNA LIGASES.

FEATURES Location/Qualifiers source 1..1131 /organism="Mus musculus" /db_xref="taxon:10090" 1..1131 Protein 1..1131 /product="ACTIVATOR 1 140 KD SUBUNIT" Region 66 /note="Y -> N (IN REF. 3)." /region_name="Conflict" Region 187 /note="E -> EPDFCLSCLIFFGIQ (IN REF. 4)." /region_name="Conflict" Region 254 /note="V -> A (IN REF. 5)." /region_name="Conflict" Region 354..528 /note="INTERFERON-STIMULATED-RESPONSE-ELEMENT BINDING REGION." /region_name="Domain" Region 398..470 /note="TO NAD-DEPENDENT DNA LIGASES." /region_name="Similarity" Region 559 /note="N -> S (IN REF. 4)." /region_name="Conflict" Region 614 /note="MISSING (IN REF. 3 AND 4)." /region_name="Conflict" Site 635..642 /note="ATP." /site_type="np-binding" Region 734..751 /note="C2HC-TYPE." /region_name="Zinc finger region" Region 945 /note="S -> N (IN REF. 1)." /region_name="Conflict" Region 1071 /note="T -> A (IN REF. 3)." /region_name="Conflict" Region 1104 /note="K -> KQ (IN REF. 4)." /region_name="Conflict" Region 1104..1108 /note="NUCLEAR LOCALIZATION SIGNAL." /region_name="Domain"

ORIGIN 1 mdirkffgvi ssgkkpvnet vknektkase gtvkgkkgvk eakvnnsgke daskpkqhsk

61 kkriiydsds eseetvqvkn akkkseklsl sykpgkvsqk dpvtyvsetd edddfvckka

121 askskengvs tnsylgtsnv kkneenvktk nkplspiklt ptsvldyfgt esvqrsgkkm

181 vtskrkessq ntedsrlnde aiakqlqlde daelerqlhe deefartlal ldeepkikka

241 rkdseegees fssvqddlsk aekqkspnka elfstarkty spakhgkgra sedakqpcks

301 ahrkeacssp kasaklalmk akeessynet ellaarrkes atepkgektt pkktkvsptk

361 resvspedse kkrtnyqayr sylnregpka lgskeipkga enclegltfv itgvlesier

421 deaksliery ggkvtgnvsk ktnylvmgrd sgqsksdkaa algtkilded glldlirtmp

481 gkrskyemaa eaemkkeksk lertpqkndq gkrkispakk eseskkcklt llknspmkav

541 kkeastcprg ldvkethgnr ssnkeecllw vdkykpaslk niigqqgdqs cankllrwlr

601 nwhksspeek khaakfgkla skddgssfka allsgppgvg ktttaslvcq elgysyveln

661 asdtrsknsl kavvaeslnn tsikgfytsg aapsvsarha limdevdgma gnedrggiqe

721 liglikhtki piicmcndrn hpkirslvhy cfdlrfqrpr veqiksamls iafkeglkip

781 ppamneiilg anqdvrqvlh nlsmwcaqsk altydqakad sqrakkdirl gpfdvtrkvf

841 aageetahms lmdksdlffh dysiaplfvq enylhvkpva aggdmkkhlm llsraadsic

901 dgdlvdnqir skqnwsllpt qaiyasvlpg elmrgymtqf psfpswlgkh sstgkhdriv

961 qdlslhmslr tysskrtvnm dylshirdal vrpltsqgve gaqhviklmd tyylmkedfe

1021 nimevsswgg kpsafskldp kvkaaftray nkeahltpys lqvvktsrls tgpaldseys

1081 eefqeddtqs ekeqdavetd amikkktrss kpsksereke skkgkgknwk k //

Return to Genbank Search page

Return to Kelly's homepage