LOCUS NM_000920
3960 bp mRNA
PRI 19-MAR-1999
DEFINITION Homo sapiens pyruvate carboxylase
(PC) mRNA.
ACCESSION NM_000920
VERSION NM_000920.1
GI:4505626
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to
3960)
AUTHORS Walker,M.E.,
Jitrapakdee,S., Val,D.L. and Wallace,J.C.
TITLE
Direct Submission
JOURNAL Submitted
(05-JUL-1995) John C. Wallace, Biochemistry, University
of Adelaide, North Terrace, Adelaide, South Australia 5005,
Australia
COMMENT REFSEQ: This
reference sequence was derived from U30891.
PROVISIONAL RefSeq: This is a provisional reference sequence record
that has not yet been subject to human review. The final curated
reference sequence record may be somewhat different from this one.
FEATURES
Location/Qualifiers
source
1..3960
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q13.4"
/tissue_type="liver and kidney"
gene
1..3960
/gene="PC"
/db_xref="LocusID:5091"
/db_xref="MIM:266150"
CDS
53..3589
/gene="PC"
/EC_number="6.4.1.1"
/codon_start=1
/db_xref="LocusID:5091"
/db_xref="MIM:266150"
/product="pyruvate carboxylase"
/protein_id="NP_000911.1"
/db_xref="GI:4505627"
/translation="MLKFRTVHGGLRLLGIRRTSTAPAASPNVRRLEYKPIKKVMVAN
RGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDI
IKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAI
AAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYT
RAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVE
IAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHT
VTEEITDVDLVHAQIHVSEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTG
RIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEF
RVRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVM
VNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVRNHPGLLLM
DTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPW
RRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNY
LPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCI
KDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAA
DSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKS
GNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIV
GDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLP
RVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPL
DSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSIL
VKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKME
TVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE"
transit_peptide
53..112
mat_peptide
113..3586
/EC_number="6.4.1.1"
/product="pyruvate carboxylase"
misc_feature
542..1051
/note="encodes ATP binding domain"
misc_feature
1745..2554
/note="encodes pyruvate binding domain"
misc_feature
3380..3586
/note="encodes biotinyl domain"
polyA_site
3960
/note="19 A nucleotides"
BASE COUNT 806
a 1221 c 1220 g 713 t
ORIGIN
1 gaattccggg aacagtgtgg cctctctgga actctgcaga ccacctgccg tgatgctgaa
61 gttccgaaca gtccatgggg gcctgaggct cctgggaatc cgccgaacct ccaccgcccc
121 cgctgcctcc
ccaaatgtcc ggcgcctgga gtataagccc atcaagaaag tcatggtggc
181 caacagaggt
gagattgcca tccgtgtgtt ccgggcctgc acggagctgg gcatccgcac
241 cgtagccatc
tactctgagc aggacacggg ccagatgcac cggcagaaag cagatgaagc
301 ctatctcatc
ggccgcggcc tggcccccgt gcaggcctac ctgcacatcc cagacatcat
361 caaggtggcc
aaggagaaca acgtagatgc agtgcaccct ggctacgggt tcctctctga
421 gcgagcggac
ttcgcccagg cctgccagga tgcaggggtc cggtttattg ggccaagccc
481 agaagtggtc
cgcaagatgg gagacaaggt ggaggcccgg gccatcgcca ttgctgcggg
541 tgttcccgtt
gtccctggca cagatgcccc catcacgtcc ctgcatgagg cccacgagtt
601 ctccaacacc
tacggcttcc ccatcatctt caaggcggcc tatgggggtg gagggcgtgg
661 catgagggtg
gtgcacagct acgaggagct ggaggagaat tacacccggg cctactcaga
721 ggctctggcc
gcctttggga atggggcgct gtttgtggag aagttcatcg agaagccacg
781 gcacatcgag
gtgcagatct tgggggacca gtatgggaac atcctgcacc tgtacgagcg
841 agactgctcc
atccagcggc ggcaccagaa ggtggtcgag attgcccccg ccgcccacct
901 ggacccgcag
cttcggactc ggctcaccag cgactctgtg aaactcgcta aacaggtggg
961 ctacgagaac
gcaggcaccg tggagttcct ggtggacagg cacggcaagc actacttcat
1021 cgaggtcaac
tcccgcctgc aggtggagca cacggtcaca gaggagatca ccgacgtaga
1081 cctggtccat
gctcagatcc acgtgtctga gggcaggagc ctacccgacc tgggcctgcg
1141 gcaggagaac
atccgcatca acgggtgtgc catccagtgc cgggtcacca ccgaggaccc
1201 cgcgcgcagc
ttccagccgg acaccggccg cattgaggtg ttccggagcg gagagggcat
1261 gggcatccgc
ctggataatg cttccgcctt ccaaggagcc gtcatctcgc cccactacga
1321 ctccctgctg
gtcaaagtca ttgcccacgg caaagaccac cccacggccg ccaccaagat
1381 gagcagggcc
cttgcggagt tccgcgtccg aggtgtgaag accaacatcg ccttcctgca
1441 gaatgtgctc
aacaaccagc agttcctggc aggcactgtg gacacccagt tcatcgacga
1501 gaacccagag
ctgttccagc tgcggcctgc acagaaccgg gcccaaaagc tgttgcacta
1561 cctcggccat
gtcatggtaa acggtccaac caccccgatt cccgtcaagg ccagccccag
1621 ccccacggac
cccgttgtcc ctgcagtgcc cataggcccg cccccggctg gtttcagaga
1681 catcctgctg
cgagaggggc ctgagggctt tgctcgagct gtgcggaacc acccggggct
1741 gctgctgatg
gacacgacct tcagggacgc ccaccagtca ctgctggcca ctcgtgtgcg
1801 cacccacgat
ctcaaaaaga tcgcccccta tgttgcccac aacttcagca agctcttcag
1861 catggagaac
tggggaggag ccacgtttga cgtcgccatg cgcttcctgt atgagtgccc
1921 ctggcggcgg
ctgcaggagc tccgggagct catccccaac atccctttcc agatgctgct
1981 gcggggggcc
aatgctgtgg gctacaccaa ctacccagac aacgtggtct tcaagttctg
2041 tgaagtggcc
aaagagaatg gcatggatgt cttccgtgtg tttgactccc tcaactactt
2101 gcccaacatg
ctgctgggca tggaggcggc aggaagtgcc ggaggcgtgg tggaggctgc
2161 catctcatac
acgggcgacg tggccgaccc cagccgcacc aagtactcac tgcagtacta
2221 catgggcttg
gccgaagagc tggtgcgagc tggcacccac atcctgtgca tcaaggacat
2281 ggccgggctg
ctgaagccca cggcctgcac catgctggtc agctccctcc gggaccggtt
2341 ccccgacctc
ccactgcaca tccacaccca cgacacgtca ggggcaggcg tggcagccat
2401 gctggcctgt
gcccaggctg gagctgatgt ggtggatgtg gcagctgatt ccatgtctgg
2461 gatgacttca
cagcccagca tgggggccct ggtggcctgt accagaggga ctcccctgga
2521 cacagaggtg
cccatggagc gcgtgtttga ctacagtgag tactgggagg gggctcgggg
2581 actgtacgcg
gccttcgact gcacggccac catgaagtct ggcaactcgg acgtgtatga
2641 aaatgagatc
ccagggggcc agtacaccaa cctgcacttc caggcccaca gcatggggct
2701 tggctccaag
ttcaaggagg tcaagaaggc ctatgtggag gccaaccaga tgctgggcga
2761 tctcatcaag
gtgacgccct cctccaagat cgtgggggac ctggcccagt ttatggtgca
2821 gaatggattg
agccgggcag aggccgaagc tcaggcggaa gagctgtcct ttccccgctc
2881 cgtggtggag
ttcctgcagg gctacatcgg tgtcccccat ggggggttcc ccgaaccctt
2941 tcgctctaag
gtactgaagg acctgccaag ggtggagggg cggcctggag cctccctccc
3001 tcccctggat
ctgcaggcac tggagaagga gctggtagac cggcatgggg aggaggtgac
3061 gccggaagat
gtgctctcag cagctatgta ccccgatgtg tttgcccact tcaaggactt
3121 cactgccacc
tttggccccc tggatagcct gaatactcgc ctcttcctgc agggacccaa
3181 gatcgcagag
gagtttgagg tggagctgga gcggggcaag acgctgcaca tcaaagccct
3241 ggccgtgagc
gacctgaacc gggccggcca gaggcaggtc ttctttgagc tcaatgggca
3301 gctgcggtcc
atcttggtca aggacaccca ggccatgaag gagatgcact tccaccccaa
3361 ggccctaaag
gacgtgaagg gccagatcgg ggcgcccatg cctgggaagg tgatagacat
3421 caaagtggtg
gcaggggcca aggtggccaa gggccagccc ctgtgtgtgc tcagtgccat
3481 gaagatggag
actgtggtga cctcacccat ggagggtact gtccgcaagg ttcatgtgac
3541 caaggacatg
acactggaag gtgacgacct catcctggag atcgagtgat cttgccccag
3601 accggcagcc
tggccatccc caagccttca acagaagctg tgctgccacg gcaggcccag
3661 gccagccagt
gcccgaggcc aggaaggccg ggccgtggag gtcctgtcca cagctggaca
3721 ggagagacac
cgctgcggtg gttcattcct ttcagccatc gtcctttctc cggcggacag
3781 ctgcttacat
gttcatctct tgccaaataa gggtcccctc ctcactggag actacaagtg
3841 gtgggtcagg
tggtcctagg acccagggga ggtttagggg tcctatctcc tgggggaagg
3901 ggagatctaa
gatgtcccag gtcctgggaa gtttactcaa taaagctggc tttcccctgc
//
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