LOCUS       RNU36585     4024 bp    mRNA            ROD       26-JUL-1996
     DEFINITION  Rattus norvegicus pyruvate carboxylase mRNA, complete cds.
     ACCESSION   U36585
     VERSION     U36585.1  GI:1040973
     KEYWORDS    .
     SOURCE      Norway rat strain=Wistar.
       ORGANISM  Rattus norvegicus
                 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
                 Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus.
     REFERENCE   1  (bases 1 to 4024)
       AUTHORS   Jitrapakdee,S., Booker,G.W., Cassady,A.I. and Wallace,J.C.
       TITLE     Cloning, sequencing and expression of rat liver pyruvate
                 carboxylase
       JOURNAL   Biochem. J. 316 (Pt 2), 631-637 (1996)
       MEDLINE   96257760
     REFERENCE   2  (bases 1 to 4024)
       AUTHORS   Jitrapakdee,S., Booker,G.W., Cassady,A.I. and Wallce,J.C.
       TITLE     Direct Submission
       JOURNAL   Submitted (18-SEP-1995) John C. Wallace, Biochemistry, University
                 of Adelaide, North Terrace, Adelaide, South Australia 5005,
                 Australia
     FEATURES             Location/Qualifiers
          source          1..4024
                          /organism="Rattus norvegicus"
                          /strain="Wistar"
                          /db_xref="taxon:10116"
                          /tissue_type="liver"
          misc_feature    67..246
                          /note="encodes mitochondrial targetting sequence"
          CDS             67..3603
                          /EC_number="6.4.1.1"
                          /codon_start=1
                          /product="pyruvate carboxylase"
                          /protein_id="AAC52668.1"
                          /db_xref="GI:1040974"
                          /translation="MLKFQTVRGGLRLLGVRRSSTAPVASPNVRRLEYKPIKKVMVAN
                          RGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDI
                          IKVAKENGVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAI
                          AAGVPVVPGTNSPINSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYT
                          RAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVE
                          IAPATHLDPQLRSRLTSDSVKLAKQVGYENAGTVEFLVDKHGKHYFIEVNSRLQVEHT
                          VTEEITDVDLVHAQIHVSEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTG
                          RIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEF
                          RVRGVKTNIPFLQNVLNNQQFLAGIVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVM
                          VNGPTTPIPVKVSPSPVDPIVPVVPIGPPPAGFRDILLREGPEGFARAVRNHQGLLLM
                          DTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFNNLFSIENWGGATFDVAMRFLYECPW
                          RRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRIFDSLNY
                          LPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLEYYMGLAEELVRAGTHILCI
                          KDMAGLLKPAACTMLVSSLRDRFPDLPLHIHTHDTSGSGVAAMLACAQAGADVVDVAV
                          DSMSGMTSQPSMGALVACTKGTPLDTEVPLERVFDYSEYWEGARGLYAAFDCTATMKS
                          GNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIV
                          GDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGIPHGGFPEPFRSKVLKDLP
                          RIEGRPGASLPPLNLKELEKDLIDRHGEEVTPEDVLSAAMYPDVFAQFKDFTATFGPL
                          DSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSIL
                          VKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDVKVAAGAKVVKGQPLCVLSAMKME
                          TVVTSPMEGTIRKVHVTKDMTLEGDDLILEIE"
          misc_feature    556..1503
                          /note="encodes ATP/HCO3-binding domain"
          misc_feature    1758..2826
                          /note="encodes pyruvate-binding domain"
          misc_feature    3394..3599
                          /note="encodes biotinyl domain"
     BASE COUNT      938 a   1118 c   1133 g    835 t
     ORIGIN
             1 gttccctgtc agtggaggca acggccgtca gaggcggcgg ccacggcttg aggcgacggg
            61 gcgaagatgc tgaagttcca aacagttcga gggggcctga ggctcctggg tgtccgccga
           121 tcctccacag cccccgttgc ctccccaaat gtccggcgtc tggagtacaa gcccatcaag
           181 aaagtaatgg tggccaacag aggtgagatt gccatccgag tgtttcgtgc ctgcacagag
           241 ctgggtatcc gcacagtggc tgtctactcg gagcaggaca cagggcagat gcaccggcag
           301 aaagctgatg aagcctacct tattggccgt gggctggctc ctgtgcaagc ctacctgcac
           361 attccagaca tcattaaggt ggccaaggag aatggtgtag atgctgtgca ccctggctat
           421 gggttcctct cagagagagc agactttgcc caggcctgcc aagatgctgg agtccgattc
           481 attggtccaa gcccagaggt ggtccgcaag atgggagaca aggtggaagc ccgggccatt
           541 gccattgctg caggcgttcc agtggtccct ggcactaatt cccccatcaa ttccctgcat
           601 gaggcacacg agttctctaa cacctatggt ttccctatta tcttcaaggc tgcctatgga
           661 ggtgggggcc gtggcatgag ggttgtgcat agctacgagg agctggaaga gaattacacc
           721 cgggcctact ctgaggcctt ggcagccttt gggaatgggg cattgtttgt ggagaaattc
           781 attgagaagc caagacacat tgaggtgcag atcctagggg accaatatgg gaacatcttg
           841 cacttgtatg agcgggactg ctccatccag cggcggcacc agaaggtcgt cgagattgcc
           901 cctgctaccc acctggaccc ccaacttcgg tcacgcctca ccagtgactc tgtcaaactt
           961 gccaagcagg ttggctatga gaatgcaggc actgtcgagt tcctggtgga caagcatggc
          1021 aagcactact tcatcgaggt caattcccgc ctgcaggtgg agcacacggt cactgaggag
          1081 attacagatg tggacctggt ccatgctcag atccatgtct ccgaaggccg gagcctgcct
          1141 gacctggggc tgcggcagga aaacatccga atcaatggtt gtgccattca gtgtcgggtc
          1201 accactgagg accctgcacg cagcttccag ccagacactg gccgcattga ggttttccgg
          1261 agtggtgagg gcatgggcat ccgcctggac aatgcctcag cattccaggg agctgtcata
          1321 tccccccact atgactccct gctggtcaaa gtcattgccc atggcaaaga ccaccctaca
          1381 gctgccacca agatgagcag agccctggcg gagttccgtg tccgaggtgt aaagaccaac
          1441 atccccttcc tgcagaatgt tctcaacaac cagcagttcc tagcgggcat tgtggacacc
          1501 cagttcatcg atgagaaccc cgagctgttc cagctgcggc ctgcacagaa ccgggcccag
          1561 aagttgctac attaccttgg acacgtcatg gtcaatggcc ctaccactcc aatccccgtc
          1621 aaggtcagtc ccagccctgt ggaccccatt gttcctgtgg tgcccatagg cccaccccca
          1681 gctggtttca gagacatcct tctgcgagag gggccagagg gctttgccag agctgtgcgg
          1741 aatcaccagg ggctgctgct aatggacaca accttccggg atgcccacca gtcactactt
          1801 gccactagag tgcgcacaca cgatctcaaa aagattgcac cctacgttgc ccacaacttc
          1861 aacaacctct tcagcataga gaactgggga ggagccacat ttgacgtggc catgcgcttc
          1921 ttgtatgagt gcccctggcg gcggctccag gagctccggg agctcatccc caacatccca
          1981 ttccagatgc tactgagggg ggccaatgct gtgggctaca ccaactaccc tgacaacgtg
          2041 gtcttcaagt tctgtgaggt ggccaaagag aatggcatgg acgtcttccg gatctttgac
          2101 tcccttaact acctgccaaa catgctgctg ggcatggaag cagctggcag tgctgggggt
          2161 gtggtggaag ctgccatctc ctacacgggt gacgtggctg accccagtcg cactaaatac
          2221 tcactggagt actacatggg cttagctgaa gaactggtgc gagccggcac tcacatcctc
          2281 tgcattaagg acatggcagg cctgctgaag cctgcagcat gcaccatgct ggtcagctcc
          2341 ctccgggacc ggttccccga cctcccactg cacatccata cccatgacac atcagggtca
          2401 ggtgtggcag ccatgttggc ctgtgcacaa gctggggctg atgttgtgga tgtggcagtc
          2461 gactctatgt ctgggatgac ctcacagccc agcatggggg ccctggtggc ctgtaccaaa
          2521 gggactcctc tggacacaga ggtacccctg gagcgtgtgt ttgactacag tgagtattgg
          2581 gaaggggctc gggggctgta tgcagccttt gattgcacgg ctaccatgaa gtctggcaac
          2641 tcagacgtgt atgagaatga gatcccaggg ggccagtaca ccaacctaca cttccaggcc
          2701 cacagcatgg gacttggctc caagttcaag gaggtcaaga aggcctatgt ggaggctaac
          2761 cagatgctgg gggacctcat caaggtgaca ccatcctcca agattgtggg ggatctggcc
          2821 cagttcatgg tgcagaacgg gttgagccgg gcagaggcag aagctcaggc agaagagctg
          2881 tccttccccc gctctgtggt ggagttcctc cagggctaca ttggcattcc ccatgggggt
          2941 ttccctgaac ccttccgttc taaggtgcta aaggacctgc caagaataga agggaggcct
          3001 ggagcctccc tccctccctt gaacctgaag gagctggaga aggacctgat tgataggcat
          3061 ggagaggagg tgaccccaga ggacgttctc tctgcagcca tgtaccctga tgtctttgct
          3121 cagttcaaag acttcacggc tacctttggc cccctggata gcctgaatac tcgtctcttt
          3181 cttcaaggac ccaaaattgc agaggagttt gaggttgagc tggaacgggg caagaccttg
          3241 cacatcaaag ccctggctgt aagcgacctg aaccgtgctg gccagaggca ggtgttcttt
          3301 gaactcaatg ggcagcttcg atccattctg gttaaagaca cccaggccat gaaggagatg
          3361 cacttccatc ccaaggcctt gaaggatgtg aagggccaaa ttggggcccc tatgcctggg
          3421 aaggtcatag acgtcaaggt ggcagcagga gccaaggtgg ttaagggcca gcccctctgt
          3481 gtgctcagcg ccatgaagat ggagactgtg gtgacttcgc ccatggaggg cactatccga
          3541 aaggttcacg tgaccaagga catgactctg gaaggcgatg acctcatcct agagattgag
          3601 tgatcttact ccagactggc agcctggcca accctacccc aagcctctca acagaagctg
          3661 tgcagccagg gcaggcccag gcagtacctg agctagccct tgaggtcctg tcccatggga
          3721 cagcacacac actacctgca atggccctcc cattcccttc agctatttgt ccttgtcttg
          3781 ctggcaaggc agttctcaca tattcatctc ttgccaaata agggtctgct cctcgtggga
          3841 gaccacaggt gtacagtagg tggccttgta cctgggagag gggttctacc tctgggggta
          3901 gagggaagaa gacctaattc ataggtcctg ggaaatttgc tcaataaaag tggccttccc
          3961 ttgccctcca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
          4021 aaaa

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