M80397 . Human DNA polymera...[gi:181619]
PubMed, Protein, Related Sequences, LinkOut
LOCUS HUMDNAPOLC
3443 bp mRNA
PRI 31-DEC-1994
DEFINITION Human DNA polymerase delta
catalytic subunit mRNA, complete cds.
ACCESSION M80397
VERSION M80397.1
GI:181619
KEYWORDS DNA polymerase-delta
catalytic subunit.
SOURCE Homo
sapiens liver cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to
3443)
AUTHORS Chung,D.W.,
Zhang,J.A., Tan,C.K., Davie,E.W., So,A.G. and
Downey,K.M.
TITLE
Primary structure of the catalytic subunit of human DNA polymerase
delta and chromosomal location of the gene
JOURNAL Proc. Natl.
Acad. Sci. U.S.A. 88 (24), 11197-11201 (1991)
MEDLINE 92107916
FEATURES
Location/Qualifiers
source
1..3443
/organism="Homo sapiens"
/db_xref="taxon:9606"
/cell_line="HepG2"
/cell_type="hepatocyte"
/tissue_type="liver"
gene
54..3377
/gene="DNA polymerase delta catalytic subunit"
CDS
54..3377
/gene="DNA polymerase delta catalytic subunit"
/codon_start=1
/product="DNA polymerase-delta catalytic-subunit"
/protein_id="AAA58439.1"
/db_xref="GI:181620"
/translation="MDGKRRPGPGPGVPPKRARGGLWDDDDAPWPSQFEEDLALMEEM
EAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEID
HYVGPAQPVPGGPPPSRGSVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEH
MGDLQRELNLAISRDSRGGRELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPR
LVAPARRLLEQGIRVAGLGTPSFAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALR
LKEKATQCQLEADVLWSDVVSHPPEGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPV
IQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYEKEEDLLQAWSTFIRIMDPDV
ITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVS
MVGRVQMDMLQVLLREYKLRSHTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQTRRRL
AVYCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQAMHE
GLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRP
GTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLR
RQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYT
VENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVY
FPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRD
PEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGS
APSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEP
ILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFCQ
PRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKD
LEDQEQLLRRFGPPGPEAW"
BASE COUNT 621
a 1109 c 1120 g 593 t
ORIGIN
1 agtcaggggt cacggcggcg taggctgtgg cgggaaacgc tgtttgaagc gggatggatg
61 gcaagcggcg gccaggccca gggcccgggg tgcccccaaa gcgggcccgt gggggcctct
121 gggatgatga
tgatgcacct tggccatccc aattcgagga ggacctggca ctgatggagg
181 agatggaggc
agaacacagg ctgcaggagc aggaggagga ggagctgcag tcagtcctgg
241 agggggttgc
agacgggcag gtcccaccat cagccataga tcctcgctgg cttcggccca
301 caccaccagc
gctggacccc cagacagagc ccctcatctt ccaacagttg gagattgacc
361 attatgtggg
cccagcgcag cctgtgcctg gggggccccc accatcccgc ggctccgtgc
421 ctgtgctccg
cgccttcggg gtcaccgatg aggggttctc tgtctgctgc cacatccacg
481 gcttcgctcc
ctacttctac accccagcgc cccctggttt cgggcccgag cacatgggtg
541 acctgcaacg
ggagctgaac ttggccatca gccgggacag tcgcgggggg agggagctga
601 ctgggccggc
cgtgctggct gtggaactgt gctcccgaga gagcatgttt gggtaccacg
661 ggcacggccc
ctccccgttc ctgcgcatca ccgtggcgct gccgcgcctc gtggccccgg
721 cccgccgtct
cctggaacag ggcatccgtg tggcaggcct gggcacgccc agcttcgcgc
781 cctacgaggc
caacgtcgac tttgagatcc ggttcatggt ggacacggac atcgtcggct
841 gcaactggct
ggagctccca gctgggaaat acgccctgag gctgaaggag aaggctacgc
901 agtgccagct
ggaggcggac gtgctgtggt ctgacgtggt cagtcaccca ccggaagggc
961 catggcagcg
cattgcgccc ttgcgcgtgc tcagcttcga tatcgagtgc gccggccgca
1021 aaggcatctt
ccctgagcct gagcgggacc ctgtcatcca gatctgctcg ctgggcctgc
1081 gctgggggga
gccggagccc ttcctacgcc tggcgctcac cctgcggccc tgtgccccca
1141 tcctgggtgc
caaggtgcag agctacgaga aggaggagga cctgctgcag gcctggtcca
1201 ccttcatccg
tatcatggac cccgacgtga tcaccggtta caacatccag aacttcgacc
1261 ttccgtacct
catctctcgg gcccagaccc tcaaggtaca aacattccct ttcctgggcc
1321 gtgtggccgg
cctttgctcc aacatccggg actcttcatt ccagtccaag cagacgggcc
1381 ggcgggacac
caaggttgtc agcatggtgg gccgcgtgca gatggacatg ctgcaggtgc
1441 tgctgcggga
gtacaagctc cgctcccaca cgctcaatgc cgtgagcttc cacttcctgg
1501 gcgagcagaa
ggaggacgtg cagcacagca tcatcaccga cctgcagaat gggaacgacc
1561 agacccgccg
ccgcctggct gtgtactgcc tgaaggatgc ctacctgcca ctgcggctgc
1621 tggagcggct
catggtgctg gtgaacgccg tggagatggc gagggtcact ggcgtgcccc
1681 tcagctacct
gctcagtcgt ggccagcagg tcaaagtcgt atcccagctg ttgcggcagg
1741 ccatgcacga
ggggctgctg atgcccgtgg tgaagtcaga gggcggcgag gactacacgg
1801 gagccactgt
catcgagccc ctcaaagggt actacgacgt ccccatcgcc accctggact
1861 tctcctcgct
gtacccgtcc atcatgatgg cccacaacct gtgttacacc acgctccttc
1921 ggcccgggac
tgcacagaaa ctgggcctga ctgaggatca gttcatcagg acccccaccg
1981 gggacgagtt
tgtgaagacc tcagtgcgga aggggctgct gccccagatc ctggagaacc
2041 tgctcagtgc
ccggaagagg gccaaggccg agctggccaa ggagacagac cccctccggc
2101 gccaggtcct
ggatggacgg cagctggcgc tgaaggtgag cgccaactcc gtatacggct
2161 tcactggcgc
ccaggtgggc aagttgccgt gcctggagat ctcacagagc gtcacggggt
2221 tcggacgtca
gatgatcgag aaaaccaagc agctggtgga gtctaagtac acagtggaga
2281 atggctacag
caccagtgcc aaggtggtgt atggtgacac tgactccgtc atgtgccgat
2341 tcggcgtgtc
ctcggtggct gaggcgatgg ccctggggcg ggaggccgcg gactgggtgt
2401 caggtcactt
cccgtcgccc atccggctgg agtttgagaa ggtctacttc ccatacctgc
2461 ttatcagcaa
gaagcgctac gcgggcctgc tcttctcctc ccggcccgac gcccacgacc
2521 gcatggactg
caagggcctg gaggccgtgc gcagggacaa ctgccccctc gtggccaacc
2581 tggtcactgc
ctcactgcgc cgcctgctca tcgaccgaga ccctgagggc gcggtggctc
2641 acgcacagga
cgtcatctcg gacctgctgt gcaaccgcat cgatatctcc cagctggtca
2701 tcaccaagga
gctgacccgc gcggcctccg actatgccgg caagcaggcc cacgtggagc
2761 tggccgagag
gatgaggaag cgggaccccg ggagtgcgcc cagcctgggc gaccgcgtcc
2821 cctacgtgat
catcagtgcc gccaagggtg tggccgccta catgaagtcg gaggacccgc
2881 tgttcgtgct
ggagcacagc ctgcccattg acacgcagta ctacctggag cagcagctgg
2941 ccaagcccct
cctgcgcatc ttcgagccca tcctgggcga gggccgtgcc gaggctgtgc
3001 tactgcgggg
ggaccacacg cgctgcaaga cggtgctcac gggcaaggtg ggcggcctcc
3061 tggccttcgc
caaacgccgc aactgctgca ttggctgccg cacagtgctc agccaccagg
3121 gagccgtgtg
tgagttctgc cagccccggg agtctgagct gtatcagaag gaggtatccc
3181 atctgaatgc
cctggaggag cgcttctcgc gcctctggac gcagtgccag cgctgccagg
3241 gcagcctgca
cgaggacgtc atctgcacca gccgggactg ccccatcttc tacatgcgca
3301 agaaggtgcg
gaaggacctg gaagaccagg agcagctcct gcggcgcttc ggaccccctg
3361 gacctgaggc
ctggtgacct tgcaagcatc ccatggggcg ggggcgggac cagggagaat
3421 taataaagtt
ctggactttt gct
//