LOCUS
H10_MOUSE 194 aa
ROD 15-JUL-1999
DEFINITION HISTONE H1' (H1.0) (H1(0)).
ACCESSION P10922
PID
g1346247
VERSION P10922
GI:1346247
DBSOURCE swissprot: locus
H10_MOUSE, accession P10922;
class: standard.
created: Jul 1, 1989.
sequence updated: Feb 1, 1996.
annotation updated: Jul 15, 1999.
xrefs: gi: 51312, gi: 51313, gi: 897829, gi: 897830, gi: 90617
xrefs (non-sequence databases): HSSP P02259, MGD MGI:95893, PFAM
PF00538
KEYWORDS Chromosomal protein;
Nuclear protein; DNA-binding; Multigene
family.
SOURCE house
mouse.
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
REFERENCE 1 (residues 1
to 194)
AUTHORS Alonso,A.,
Breuer,B., Bouterfa,H. and Doenecke,D.
TITLE
Early increase in histone H1(0) mRNA during differentiation of F9
cells to parietal endoderm
JOURNAL EMBO J. 7
(10), 3003-3008 (1988)
MEDLINE 89030592
REMARK SEQUENCE
FROM N.A.
REFERENCE 2 (residues 1
to 194)
AUTHORS Dong,Y., Liu,D.
and Skoultchi,A.I.
TITLE
An upstream control region required for inducible transcription of
the mouse H1(zero) histone gene during terminal differentiation
JOURNAL Mol. Cell.
Biol. 15 (4), 1889-1900 (1995)
MEDLINE 95198706
REMARK SEQUENCE
FROM N.A.
STRAIN=BALB/C
COMMENT On Jun 1,
1996 this sequence version replaced gi:121898.
-------------------------------------------------------------------
This SWISS-PROT entry is copyright. It is produced through a
collaboration between the Swiss Institute of Bioinformatics and
the EMBL outstation - the European Bioinformatics Institute.
The original entry is available from http://www.expasy.ch/sprot
and http://www.ebi.ac.uk/sprot
------------------------------------------------------------------.
[FUNCTION] HISTONES H1 ARE NECESSARY FOR THE CONDENSATION OF
NUCLEOSOME CHAINS INTO HIGHER ORDER STRUCTURES.
[FUNCTION] THE H1'/H1.0 HISTONES ARE FOUND IN CELLS THAT ARE IN
TERMINAL STAGES OF DIFFERENTIATION OR THAT HAVE LOW RATES OF CELL
DIVISION. STRUCTURALLY AND FUNCTIONALLY THE H1' FAMILY APPEARS
INTERMEDIATE WITH RESPECT TO THE H1 AND H5 FAMILIES.
[SUBCELLULAR LOCATION] NUCLEAR.
[SIMILARITY] BELONGS TO THE HISTONE H1/H5 FAMILY.
FEATURES
Location/Qualifiers
source
1..194
/organism="Mus musculus"
/db_xref="taxon:10090"
1..194
Protein
1..194
/product="HISTONE H1'"
Region
23..97
/region_name="Domain"
/note="GLOBULAR."
Region
65
/region_name="Conflict"
/note="D -> N (IN REF. 1)."
Region
190
/region_name="Conflict"
/note="A -> G (IN REF. 1)."
ORIGIN
1 mtenstsapa akpkrakask kstdhpkysd mivaaiqaek nragssrqsi qkyikshykv
61 genadsqikl sikrlvttgv lkqtkgvgas gsfrlakgde pkrsvafkkt kkevkkvatp
121 kkaakpkkaa
skapskkpka tpvkkakkkp aatpkkakkp kvvkvkpvka skpkkaktvk
181 pkakssakra
skkk