Warning: This web page was produced as an assignment for an undergraduate course at Davidson College.
MacDNAsis Analysis of Smooth Muscle Myosin

-Image of amino acids

-There are 173 amino acids in this protein with a molecular weight of 19869.27 KD
-For the sequence of this cDNA click here
 
 

2) According to the Kyte Doolittle Hydrophathy Plot, there is two possible regions above 1.8 which suggests it is an integral protein with one or more transmembrane domains.

3) Here is an Antigenicity Plot using Hopp and Woods method:

4) Here is an image of the predicted secondary structure of the human smooth muscle myosin protein:

5) Here is a multiple sequence alignment of all five proteins:

For links back to each species' amino acid sequence for smooth muscle myosin click on any of the following:
 
 

*These two links only seem to work on Internet Explorer.

6) Here is a phylogenetic tree with all five proteins.  This shows amino acid conservation over time.

  This tree reveals that the sequences have little conservation showing that there is very little homology between species.

  Here is the homology comparison between sequences:

For links back to each species' amino acid sequence for smooth muscle myosin click on any of the following:
 
 

*These two links only seem to work on Internet Explorer.

For further molecular biology information, see the Molecular Biology Home Page.

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-For more information about this site, contact  Jomckillop@Davidson.edu