Homo
sapiens
LOCUS HUMTPI
1835 bp mRNA PRI 07-AUG-1995
DEFINITION Human
triosephosphate isomerase mRNA, complete cds.
ACCESSION M10036
M10037
VERSION M10036.1
GI:339840
KEYWORDS triose-phosphate
isomerase.
SOURCE Human
adult liver, cDNA to mRNA, clone pHTPI-5a [3],[2]; DNA, clone
lambda-hTPI-8B
[3].
ORGANISM Homo
sapiens
Eukaryota;
Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases
)
AUTHORS Maquat,L.
JOURNAL Unpublished
REFERENCE 2 (bases
369 to 1562)
AUTHORS Maquat,L.E.,
Chilcote,R. and Ryan,P.M.
TITLE Human
triosephosphate isomerase cDNA and protein structure. Studies
of
triosephosphate isomerase deficiency in man
JOURNAL J.
Biol. Chem. 260 (6), 3748-3753 (1985)
MEDLINE 85131186
REFERENCE 3 (bases
1 to 1835)
AUTHORS Brown,J.R.,
Daar,I.O., Krug,J.R. and Maquat,L.E.
TITLE Characterization
of the functional gene and several processed
pseudogenes in
the human triosephosphate isomerase gene family
JOURNAL Mol.
Cell. Biol. 5 (7), 1694-1706 (1985)
MEDLINE 85267686
COMMENT Draft
entry and sequence in computer-readable form [3],[2] kindly
provided by
L.Maquat, 30-JUL-1985.
The variations
annotated in the FEATURES table are silent and
probably occurred
because the DNA for sequencing was obtained from
different
individuals.
[1] revision.
FEATURES Location/Qualifiers
source 1..1835
/organism="Homo
sapiens"
/db_xref="taxon:9606"
/map="12p13"
mRNA 334..1562
/product="TPI
mRNA"
gene 368..1117
/gene="TPI1"
CDS 368..1117
/gene="TPI1"
/note="triosephosphate
isomerase (EC 5.3.1.1)"
/codon_start=1
/protein_id="AAB59511.1"
/db_xref="GI:339841"
/translation="MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAP
PTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHV
FGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSK
VVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATC
KELASQPDVDGFLVGGASLKPEFVDIINAKQ"
variation 652
/gene="TPI1"
/note="a in [2]; g in
[3]"
/replace="g"
old_sequence 856
/gene="TPI1"
/citation=[2]
BASE COUNT 399 a 495 c 541 g 400 t
ORIGIN 261 bp upstream of NcoI site; chromosome 12.
1 accagctagt tccgcttgaa aaccacttct ggccccgtgg gggactcaag
tcgccaagcg
61 agggttcccc tgagcgccgg agctcacagg tctcgccttg tcccgaaagc
cccgcaatcg
121 aggcggaggc gaccgagccc ccgactctcc tagaacgttg ccacaagaag
ggggaacgtc
181 ggaacagtgc atcatcgggc ggcggccggg gcggcggcag gagggcgggc
ggggggcagg
241 gctccggggg actgggcggg ccatggcgga ggacggcgag gaggcggagt
tccacttcgc
301 ggcgctctat ataagtgggc agtggccgac tgcgcgcgac actgaccttc
agcgcctcgg
361 ctcggccatg gcgccctcca ggaagttctt cgttggggga aactggaaga
tgaacgggcg
421 gaagcagagt ctgggggagc tcatcggcac tctgaacgcg gccaaggtgc
cggccgacac
481 cgaggtggtt tgtgctcccc ctactgccta tatcgacttc gcccggcaga
agctagatcc
541 caagattgct gtggctgcgc agaactgcta caaagtgact aatggggctt
ttactgggga
601 gatcagccct ggcatgatca aagactgcgg agccacgtgg gtggtcctgg
gacactcaga
661 gagaaggcat gtctttgggg agtcagatga gctgattggg cagaaagtgg
cccatgctct
721 ggcagaggga ctcggagtaa tcgcctgcat tggggagaag ctagatgaaa
gggaagctgg
781 catcactgag aaggttgttt tcgagcagac aaaggtcatc gcagataacg
tgaaggactg
841 gagcaaggtc gtcctcgcct atgagcctgt gtgggccatt ggtactggca
agactgcaac
901 accccaacag gcccaggaag tacacgagaa gctccgagga tggctgaagt
ccaacgtctc
961 tgatgcggtg gctcagagca cccgtatcat ttatggaggc tctgtgactg
gggcaacctg
1021 caaggagctg gccagccagc ctgatgtgga tggcttcctt gtgggtggtg
cttccctcaa
1081 gcccgaattc gtggacatca tcaatgccaa acaatgagcc ccatccatct
tccctaccct
1141 tcctgccaag ccagggacta agcagcccag aagcccagta actgcccttt
ccctgcatat
1201 gcttctgatg gtgtcatctg ctccttcctg tggcctcatc caaactgtat
cttcctttac
1261 tgtttatatc ttcaccctgt aatggttggg accaggccaa tcccttctcc
acttactata
1321 atggttggaa ctaaacgtca ccaaggtggc ttctccttgg ctgagagatg
gaaggcgtgg
1381 tgggatttgc tcctgggttc cctaggccct agtgagggca gaagagaaac
catcctctcc
1441 cttcttacac cgtgaggcca agatcccctc agaaggcagg agtgctgccc
tctcccatgg
1501 tgcccgtgcc tctgtgctgt gtatgtgaac cacccatgtg agggaataaa
cctagcacta
1561 ggtcttgtgg tttgtctgcc ttcactggac ttgcccagat aatcttcctt
tttgaggcag
1621 ctatataaat gatcatttgt gcaagaaaaa aaaaaaaaca agaacaggtt
tctataacaa
1681 catctcttac tatttttact tgaaaaaatg ttttgcgtag cagactgtca
tagccttgaa
1741 cgccggctcc ctttcttcct ccctccaagt ggctctgggg ctgttgattt
ccgcagagct
1801 gggttggggt aggggctcag cccaccagct ttcag
//