LOCUS       125127        780 aa                              01-FEB-1996
DEFINITION  6-PHOSPHOFRUCTOKINASE, LIVER TYPE (PHOSPHOFRUCTOKINASE 1)
            (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTO-1-KINASE ISOZYME B).
ACCESSION   125127
PID         g125127
DBSOURCE    SWISS-PROT: locus K6PL_MOUSE, accession P12382
            class: standard.
            created: Oct 1, 1989.
            sequence updated: Oct 1, 1989.
            annotation updated: Feb 1, 1996.
            xrefs: gi: 200297, gi: 515965, gi: 109512
            xrefs (non-sequence databases): HSSP P00512, MGD MGI:97547, PROSITE
            PS00433
KEYWORDS    KINASE; TRANSFERASE; GLYCOLYSIS; REPEAT; ALLOSTERIC ENZYME;
            PHOSPHORYLATION; MAGNESIUM.
SOURCE      house mouse.
  ORGANISM  Mus musculus
            Eukaryotae; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
            Rodentia; Sciurognathi; Muridae; Murinae; Mus.
REFERENCE   1  (residues 1 to 780)
  AUTHORS   Gehnrich,S.C., Gekakis,N. and Sul,H.S.
  TITLE     Liver (B-type) phosphofructokinase mRNA. Cloning, structure, and
            expression
  JOURNAL   J. Biol. Chem. 263 (24), 11755-11759 (1988)
  MEDLINE   88298847
  REMARK    SEQUENCE FROM N.A.
            TISSUE=LIVER
COMMENT     [CATALYTIC ACTIVITY] ATP + D-FRUCTOSE 6-PHOSPHATE = ADP +
            D-FRUCTOSE 1,6-BISPHOSPHATE.
            [COFACTOR] REQUIRES MAGNESIUM ION.
            [ENZYME REGULATION] ALLOSTERIC ENZYME ACTIVATED BY ADP, AMP, OR
            FRUCTOSE BISPHOSPHATE AND INHIBITED BY ATP OR CITRATE.
            [PATHWAY] KEY CONTROL STEP OF GLYCOLYSIS.
            [SUBUNIT] HOMOTETRAMER.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     1..780
     Protein         1..780
                     /product="6-PHOSPHOFRUCTOKINASE, LIVER TYPE"
                     /EC_number="2.7.1.11"
ORIGIN
        1 matvdleklr msgagkaigv ltsggdaqgm naavravtrm giyvgakvfl iyegyeglve
       61 ggenikpanw lsvsniiqlg gtiigsarck afttregrla aaynllqhgi tnlcviggdg
      121 sltganifrn ewgslleelv kegkisesta qnyahltiag lvgsidndfc gtdmtigtds
      181 alhrimevid aitttaqshq rtfvlevmgr hcgylalvsa lasgadwlfi peappedgwe
      241 nfmcerlget rsrgsrlnii iiaegaidrh gkpisssyvk dlvvqrlgfd trvtvlghvq
      301 rggtpsafdr ilsskmgmea vmalleatpd tpacvvslsg nqsvrlplme cvqvtkdvqk
      361 amdeerfdea iqlrgrsfen nwkiykllah qkvskeksnf slailnvgap aagmnaavps
      421 avrtgisegh tvyivhdgfe glakgqvqev gwhdvagwlg rggsmlgtkr tlpkphleai
      481 venlrtynih allviggfea yegvlqlvea rgryeelciv mcvipatisn nvpgtdfslg
      541 sdtavnaame scdrikqsas gtkrrvfive tmggycgyla tvtgiavgad aayvfedpfn
      601 ihdlkanveh mtekmktdiq rglvlrnekc hehyttefly nlyssegrgv fdcrtnvlgh
      661 lqqggaptpf drnygtklgv kamlwvsekl rdvyrkgrvf anapdsacvi glrkkvvafs
      721 pvtelkketd fehrmpreqw wlnlrlmlkm lahyrismad yvsgelehvt rrtlsidkgf
      781