LOCUS 125121
987 aa
01-NOV-1997
DEFINITION 6-PHOSPHOFRUCTOKINASE ALPHA SUBUNIT (PHOSPHOFRUCTOKINASE
1)
(PHOSPHOHEXOKINASE) (6PF-1-K ALPHA SUBUNIT).
ACCESSION 125121
PID g125121
DBSOURCE SWISS-PROT: locus K6P1_YEAST, accession
P16861
class: standard.
created: Aug 1, 1990.
sequence updated: Aug 1, 1990.
annotation updated: Nov 1, 1997.
xrefs: gi: 172137, gi: 172138, gi: 1323434, gi: 886908, gi: 886937,
gi: 82880
xrefs (non-sequence databases): HSSP P00512, YEPD 5860, YEPD 5870,
SGD L0001404, PROSITE PS00433
KEYWORDS KINASE; TRANSFERASE; GLYCOLYSIS; REPEAT;
ALLOSTERIC ENZYME;
PHOSPHORYLATION; MAGNESIUM.
SOURCE baker's yeast.
ORGANISM Saccharomyces cerevisiae
Eukaryotae; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales;
Saccharomycetaceae; Saccharomyces.
REFERENCE 1 (residues 1 to 987)
AUTHORS Heinisch,J., Ritzel,R.G., von Borstel,R.C.,
Aguilera,A., Rodicio,R.
and Zimmermann,F.K.
TITLE The phosphofructokinase genes
of yeast evolved from two duplication
events
JOURNAL Gene 78 (2), 309-321 (1989)
MEDLINE 89378757
REMARK SEQUENCE FROM N.A.
REFERENCE 2 (residues 1 to 987)
AUTHORS Guerreiro,P., Azevedo,D., Barreiros,T. and
Rodrigues-Pousada,C.
TITLE Sequencing of a 9.9 kb segment
on the right arm of yeast chromosome
VII reveals four open reading frames, including PFK1, the gene
coding for succinyl-CoA synthetase (beta-chain) and two ORFs
sharing homology with ORFs of the yeast chromosome VIII
JOURNAL Yeast 13 (3), 275-280 (1997)
MEDLINE 97245298
REMARK SEQUENCE FROM N.A.
STRAIN=S288C
REFERENCE 3 (residues 1 to 987)
AUTHORS van der Aart,Q.J., Kleine,K. and Steensma,H.Y.
TITLE Sequence analysis of the 43 kb
CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm
of Saccharomyces cerevisiae chromosome VII
JOURNAL Yeast 12 (4), 385-390 (1996)
MEDLINE 96267763
REMARK SEQUENCE OF 794-987 FROM N.A.
STRAIN=S288C
COMMENT [CATALYTIC ACTIVITY] ATP + D-FRUCTOSE
6-PHOSPHATE = ADP +
D-FRUCTOSE 1,6-BISPHOSPHATE.
[PATHWAY] KEY CONTROL STEP OF GLYCOLYSIS.
[SUBUNIT] HETEROOCTAMER OF 4 ALPHA AND 4 BETA CHAINS.
FEATURES
Location/Qualifiers
source
1..987
/organism="Saccharomyces cerevisiae"
/db_xref="taxon:4932"
1..987
Protein
1..987
/product="6-PHOSPHOFRUCTOKINASE ALPHA SUBUNIT"
/EC_number="2.7.1.11"
ORIGIN
1 mqsqdscygv afrsiitnde
alfkktihfy htlgfatvkd fnkfkhgens llssgtsqds
61 lrevwlesfk lsevdasgfr ipqqeatnka
qsqgallkir lvmsapidet fdtnetatit
121 yfstdlnkiv ekfpkqaekl sdtlvflkdp
mgnnitfsgl anatdsapts kdafleatse
181 deiisrassd asdllrqtlg ssqkkkkiav
mtsggdspgm naavravvrt gihfgcdvfa
241 vyegyegllr ggkylkkmaw edvrgwlseg
gtligtarsm efrkregrrq aagnlisqgi
301 dalvvcggdg sltgadlfrh ewpslvdelv
aegrftkeev apyknlsivg lvgsidndms
361 gtdstigays alericemvd yidatakshs
rafvvevmgr hcgwlalmag iatgadyifi
421 peravphgkw qdelkevcqr hrskgrrnnt
iivaegaldd qlnpvtandv kdalielgld
481 tkvtilghvq rggtavahdr wlatlqgvda
vkavleftpe tpspligile nkiirmplve
541 svkltksvat aienkdfdka islrdtefie
lyenflsttv kddgsellpv sdrlnigivh
601 vgapsaalna atraatlycl shghkpyaim
ngfsgliqtg evkelswidv enwhnlggse
661 igtnrsvase dlgtiayyfq knkldgliil
ggfegfrslk qlrdgrtqhp ifnipmclip
721 atvsnnvpgt eyslgvdtcl nalvnytddi
kqsasatrrr vfvcevqggh sgyiasftgl
781 itgavsvytp ekkidlasir editllkenf
rhdkgenrng kllvrneqas svystqllad
841 iiseaskgkf gvrtaipghv qqggvpsskd
rvtasrfavk cikfieqwnk kneaspntda
901 kvlrfkfdth gekvptvehe ddsaavicvn
gshvsfkpia nlwenetnve lrkgfevhwa
961 eynkigdils grlklraeva alaaenk