Strongylocentrotus purpuratus Genes in Development:
Cyclin
Cyclin B
Function
Cyclin B is a key regulatory protein of the cell
cycle, central to the control of the G2/M transition.
The mitotic cyclins or B-type cyclins are involved in
regulating the events of mitosis and are necessary
for movement from G2 through M. Cyclin B associates
with the cdc2 kinase in early G2 to form a complex
which, after a series of controlled phosphorylations and
dephosphorylations, becomes activated (Thatcher et al., 1995).
Protein
Subcellular location
Expression Pattern
Cyclin B appears to be zygotically activated around 8 hr
post fertilization.
In situ hybridization data indicate that the abundance of
cyclin mRNA transcripts parallels the pattern of cell divisions in
a manner similar to that found in Drosophila embryos (Kingsley et al., 1992).
Spatial distribution of cyclin B mRNA transcripts is uniform
in early development. These transcripts become enriched in or
restricted to the oral ectoderm and endoderm (tissues that
contain significant numbers of dividing cells). At the same time,
cyclin B transcripts are down-regulated
in the aboral ectoderm (Masuda and Sato, 1984).
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