Gene Networks Database

SpOtx - Spec2a interaction

• REGULATOR: SpOtx
• TARGET: Spec2a
• INTERACTION TYPE: protein-DNA
• INTERACTION RESULT: activation
• TISSUE: aboral ectoderm
• STAGE: 16-cell stage, cleavage, blastula. There is the uniform rise in SpOTX activity over this period.
• TARGET SITE: TAATCC/T
• PROOFS: site-directed mutagenesis, band-shift analysis, DNAase I footprinting, methylation interference, UV-crosslinking of protein to DNA, CAT assays, X-Gal staining
• REFERENCES: Gan & Klein, 1993; Gan et al., 1995; Mao et al., 1994, 1996