Gene Networks Database

UHF-1 - EH4 interaction

• REGULATOR: UHF-1
• TARGET: EH4
• INTERACTION TYPE: protein-DNA
• INTERACTION RESULT: activation
• TISSUE:
• STAGE: 8-h morula, 18-h embryo
• TARGET SITE: AGG(GC)GGC(GT)CACTC
• PROOFS:template commitment assay (1), electrophoretic gel retardation assay, DNase I footprinting, methylation interfference assay, UV DNA-protein cross-linking, study of deletion and base substitution mutants for transcriptional activity in the nuclear extracts, in vivo transcription assay (2)
• REFERENCES: 1) Tung et al., 1989, 1990; 2) Lee et al., 1991