Immunology Reading Schedule Spring 2003 - Davidson College Biology Dept.

Day	Sections	Notes, Comments, Links
Jan. 9	Introduction and Entrance Exam	Immunology Syllabus
Jan. 11	1.1 - 1.14	HHH - cell types HHH- bone marrow HHH- thymus HHH- lymph node HHH- spleen Lymphocytes on the move - QT movie Endocytosis by lymphocytes - QT movie Somatic Recombination - Flash Animation B Cell Development - Flash animation B cell Selection - Flash Animation JMOL view of Antibody Fab fragment with bound antigen (lysozyme)
Jan. 13	1.14 - 2.9	macrophage eating a pathogen skim complement sections Complement Cascade - by Jason Dyer Alzheimer's, and Complement TI B cell activation (also note complement receptors) NK cell receptor binding MCH I
Jan. 16	MLK Day	Campus-wide Activities
Jan. 18	2.9 - 2.29	Cytokines: - IFN-γ by Dax Allred '00; and Meredith Gramer '00 - IFN-β by Will White '00 - Lymphotoxin by Brenda Bondesen '00 - TNF - α by Rachel Wolf '00 - IL- 7 by Melanie Majure '00 - IL- 10 by Stacey Spolnik '01 - IL - 12 by Brent Wilson '00 - IL-2 γc Receptor Chemokines: Chemokine Families Chemokines in Homing Lymphocytes on the move - QT movie Tissue Distribution of Chemokines
Jan. 20	3.1 - 3.9	JMOL view of Antibody Fab fragment with bound antigen (lysozyme) antibody avidity (QT movie)
Jan. 23	3.10 - 3.19	Jmol of MHCI (select Class I MHC) Jmol of MHCII (select Class II MHC) Murine T-Cell Receptor Human TCR + HLA-A2 + HTLV-1 Peptide CD8 (N-Terminal 114 Residues) CD4 (D1D2 Fragment) CD4 (D1-D4 and dimerized) Complex Of The Human MHCI HLA-A2 & CD8
Jan. 25	4.1 - 4.10	Somatic Recombination - Flash Animation Somatic Hypermutation Mechanism JMOL view of DNA-binding protein HHH- bone marrow
Jan. 27	4.11 - 4.21	Murine T-Cell Receptor Human TCR + HLA-A2 + HTLV-1 Peptide Thymus Histology (site of TCR gene recombination) JMOL view of Antibody antibody avidity (QT movie)
Jan. 30	Clinical Day #1	(End of First Exam Material) Case studies presented in class for your analysis/diagnosis.
Feb. 1	Review Session First Exam Distributed	Quiz Questions (photo only) Clinical Case #1 Chapters 1 - 4 + Clinical Day
Feb. 3	First Exam Due	WWWorkshop Web Standards for this course Web Resources
Feb. 6	5.1 - 5.8	Loading peptide in MHCI - Flash Animation Loading peptide in MHCII - Flash Animation Endocytosis by lymphocytes - QT movie
Feb. 8	5.9 - 5.18	Human MHCIi HLA-Dr1 & Bacterial Superantigen Seb TCR β Chain+ Sec3 Superantigen Staphylococcal Enterotoxin Toxic Shock Syndrome Toxin-1 Staphylococcal Enterotoxin C2 MHC Haplotype Mapping HLA-G - by Kelly Carter '00
Feb. 10	6.1 - 6.16	TI B cell activation - Flash animation IP₃ signal transduction - Flash animation Lck - written by Emily Lampp '00 MAPK pathway - Flash animation (by Dr. Vic Lemas) JAK3 - written by Charles Haines '00 NFAT - written by Tim Deeb '00 NFAT structure - Chime image shown with DNA Quick Lesson on Apoptosis induced DNA fragments
Feb. 13	6.17 - 6.22	NFkB JMOL image IP₃ signal cascade - Flash animation TI B cell activation - Flash animation Lck - written by Emily Lampp '00 MAPK pathway - Flash animation (by Dr. Vic Lemas) Common g chain and JAK3 - by Charles Haines '00 Apoptosis Knockout Mouse method loxP + Cre recombination
Feb. 15	7.1 - 7.16	HHH - cell types HHH- bone marrow HHH- thymus B Cell Development - Flash animation T Cell Development- Flash animation (by Dr. Vic Lemas) Somatic Recombination - Flash Animation (reminder) NFkB JMOL image
Feb. 17	7.17 - 7.25	B cell Selection - Flash Animation T Cell Selection- Flash animation (by Dr. Vic Lemas)
Feb. 20	7.26 - 7.35	HHH- lymph node HHH- spleen Karyotype of translocation - see Philadelphia Chromosome OMIM information about bcl-2 (End Second Exam Material)
Feb. 22	Clinical Day #2 Review Session Second Exam Distributed	Chapters 5 - 7
Feb. 24	Second Exam Due	no class
thru 3/5	`Spring Break!`	`Wear Sunscreen!`
Mar. 6	8.1 - 8.14	Thymus Histology T Cell Selection- Flash animation (by Dr. Vic Lemas) Tc killing its target - QT Movie Human TCR + HLA-A2 + HTLV-1 Peptide Complex Of The Human MHCI HLA-A2 & CD8
Mar. 8	8.15 - 8.25	Tc killing its target - QT Movie Exocytosis Figure Human TCR + HLA-A2 + HTLV-1 Peptide Complex Of The Human MHCI HLA-A2 & CD8
Mar. 10	8.26 - 8.29	Macrophage eating a pathogen Apoptosis Pathway Apoptosis cleavage of DNA Apoptosis web Resources
Mar. 13	9.1 - 9.11	B cell Selection - Flash Animation Somatic Recombination - Flash Animation HHH- lymph node HHH- spleen TI B cell activation - Flash animation
Mar. 15	9.12 - 9.18	Complement Cascade - by Jason Dyer Chime view of Antibody Fab fragment with bound antigen (lysozyme) antibody avidity (QT movie)
Mar. 17	9.19 - 9.23	Eosinophils - HHH images Histamine - by David Lamar '01 Oxidative Burst IFN-β - by Will White '00 filariae tapeworms hookworm: them vs. Us Botflies Home Page on YFIP Due
Mar. 20	10.1 - 10.12	HHH - Hyperlinked Human Histology
Mar. 22	10.13 - 10.26	(End Third Exam Material)
Mar. 24	Clinical Day #3
Mar. 27	Review Session Third Exam Distributed	Chapters 8 - 10
Mar. 29	Third Exam Due	Web & "Term Paper" Help
Mar. 31	No class	Out of town presentation
Apr. 3	11.1 - 11.5	Plasmodium Images - by CDC Animations of infection by Brett Finlay and HHMI Bacteria Bacterial Pathogens Triggers Endocytosis - EM image Animations of infection by Brett Finlay and HHMI (click on Intracellular Infection by Salmonella in right hand column of links) Listeria - symptoms and treatment Salmonella enducing apoptosis Salmonella and "organic foods" Salmonella Fact Sheet Helminths Ascaris lumbricoides - from CDC web site on parasites and diagnosis Hookworm - from CDC web site on parasites and diagnosis Protozoan Leishmania - from CDC web site on parasites and diagnosis Leishmania - Clinical Leishmania - Immunity Leishmania - Evading Destruction Leishmania - Treatment Viruses HIV binding chemokine receptors - Flash animation by Hoffmann-La Roche
Apr. 5	11.6 - 11.18	SCID1 SCIDX1
Apr. 7	11.19 - 11.30	Life cycle of HIV (provided by Jim Sullivan of Cells Alive!) Life cycle of HIV (Roche site, with drug interactions) HIV Drug Resistance (by WHO stats on AIDS CD4 (D1D2 Fragment) CD4 (D1-D4 and dimerized)
Apr. 10	12.1 - 12.9	Eosinophils - HHH images Histamine - by David Lamar '01 Size of mite poop Aspirin (Jmol) Cox1 (Jmol) Cox1 acetylated(Jmol)
Apr. 12	12.10 - 12.18	TI B cell activation - Flash animation HHH - Germinal Center
Apr. 14	13.1 - 13.15	Autoimmune Diseases: Sjogren's Syndrome Heather Baker '00 Goodpasture's Syndrome Kelly Carter '00 Lupus (SLE) Karen Fritchie '00 & Brent Wilson '00 nucleosome structure Diabetes - Scott Hutchins '00 and Stacy Spolnik '01 and Jonathon Weed '00 Myasthenia Gravis Jennifer Starr '00 Osteoarthritis Al Vichot '01 Hemolytic Anemia Rachel Wolf '00 Multiple Sclerosis Erin Woodall '00 and Melanie Majure '00
Apr. 17	`Easter Break`	Get ready for the final sprint to graduation.....
Apr. 19	13.16 - 13.30	HLA-G - by Kelly Carter '00 MHC Haplotype Mapping Jmol of MHCI (select Class I MHC) Jmol of MHCII (select Class II MHC) Murine T-Cell Receptor
Apr. 21	13.31 - 13.39
Apr. 24	14.1 - 14.17	Hyperlinked Human Histology Images of Tumors Tc killing its target - QT Movie
Apr. 26	14.18 - 14.30	Gene Gun for DNA vaccines E. coli and Salmonella binding host cells Chemokines to Block HIV Infections? Liposomes for delivery of antigens? Immune Related Disease/Codition Web Page Due
April 28	Chapter 15 Course Evaluations	Evolution of the Immune System Help me improve my teaching.
May 1	Clinical Day #4 & Slide Show	Eye Movement Problems (End Fourth Exam Material) Fellowships For You
May 3	Review Session Final Exam Distributed	Focus on Chapters 11- 15
May 8	Final Exam @ noon	All Exams Due for All Students!

Immunology - Spring 2006

Dr. A. Malcolm Campbell

Dana 221 phone: x2692 email: macampbell

office hours: Mon. 2:00-3:30 and Tues. 10:30-noon

Reading Schedule

`Spring Break!`

`Wear Sunscreen!`

`Easter Break`

Final Exam @ noon

All Exams Due for All Students!