Unit One
Genome Sequences
Chapter 1: Genome Sequence Acquisition and Analysis
Section 1.1 Defining Genomes
- What is genomics?
- How are whole genomes sequenced?
- Why do databases contain so many partial sequences?
- How do we make sense of all these bases?
- Can we predict protein functions?
- How well are genes conserved in diverse species?
- How do you know which bases form a gene?
- How many proteins can one gene make?
Math Minutes:
1.1 What is an E-value?
Information Box:
1.1 Which draft sequence is better?
Section 1.2 What have we learned from the human genome draft sequences?
- Overview of human genome first draft.
- Can we describe a typical human gene?
- When are the data sufficient?
- Can the genome alter gene expression without changing the DNA sequence?
Information Box:
1.2 Whose DNA did we sequence?
Chapter 2: Genome Sequence Acquisition and Analysis
Section 2.1 Evolution and Genomes
- How did eukaryotes evolve?
- What is the origin of our species?
Math Minutes:
2.1 Are the hit numbers significantly different?
2.2 How do you know if the tree is right?
Section 2.2 Genomic Identifications
- How can we identify biological weapons?
- How long can DNA survive?
- How did tuberculosis reach North America?
- How are newly emerging diseases identified?
Section 2.3 Biomedical Genome Research
- Can we use genomic sequences to make new vaccines?
- Can we make new types of antibiotics?
- Can we invent new types of medications?
- How can E. coli be lethal and in our intestines at the same time?
Math Minutes:
2.3 How can you tell if base compositions are different?
