Model
The Non-Agglutinating Phenotype Likely Results from an incomplete
Glycosylation and/ or Mistargeted Delivery of Agglutinin to the
Flagellar Surface. In wild-type cells (left panel), the
agglutinins are likely processed in the Golgi, trans-Golgi network,
and/or endosomal compartments, areas of low pH generated by proton
pumps. From these compartments, the agglutinins are targeted to
the flagella. In the mutant strain described here (right panel),
the proton motive ATPase is absent so a low pH is not maintained
in the appropriate compartments. The loss of agglutination in
this mutant, therefore, likely results from an incomplete glycosylation
and/or mistargeted delivery of the agglutinin.