General Sites
Need Background Information? Places to start
looking? Definitions for terms?
Association of Biomolecular Research
Facilities
http://www.abrf.org/
Contains links to descriptions of methods.
Could be helpful for understanding journal articles
Biology Website references for
student's and teachers
http://www.hoflink.com/~house/index.html
Billed as 'Over 4,100 sites in thirteen biological areas Hyperlinks checked
frequently for accessibility'
Cell Biology Dept—U of Texas medical
branch
http://cellbio.utmb.edu/cellbio/lysosome.htm
If enter this site and use "return to menu’
at bottom -- links to many topics covered in their cell bio course
Cell and Molecular Biology Online
http://www.cellbio.com
good general link to many other websources
Dictionary of Cell Biology
http://www.mblab.gla.ac.uk/~julian/Dict.html
Was that ribosome or rhizome? Check the
dictionary and see which fits.
InScight Discussion topics
http://www.apnet.com/cgi-bin/netforum/inscight/a/1
Discussion groups on a variety of topics
brought to you by Academic Press
UCSD --Scott Emrs lab web site.
http://cmm.ucsd.edu/emr/lab/
Cool picture and some good links including
databases and online journals-- no password necessary to browse.
The Scientist-News Journal with
free subscription available
http://www.the-scientist.library.upenn.edu/homepage.htm
Can hit on just about every topic depending
on the issue
The Biology Project
http://www.biology.arizona.edu/default.html
Cell cycle link from here but good for
others too
Yale- Peter Novick’s Lab Homepage
http://info.med.yale.edu/cellbio/Links.html
Links to journals, databases, career links
(back up a link and get info on his lab’s work in vesicular traffic)
Scroll down past all of the Yale specific links to the Cell Bio ones.
Pedro's BioMolecular Research Tools
http://www.public.iastate.edu/~pedro/research_tools.html
Has a whole section of links to Guides and Tutorials
PubMed
www.ncbi.nih.gov
This is a good
link to find articles about certain areas.The site itself gives abstracts of
the articles and provides some links to see the online versions of the articles.
Definitely a 5 if you are looking for articles
Biological membranes
http://www.biology.arizona.edu/cell_bio/problem_sets/membranes/index.html
This site provides a variety of detailed information regarding the components
of cellular membranes. There are also some links to sites that provide thorough
explanations of diagrams and photos as well.
Overall Rating: 5
http://cellbio.utmb.edu/cellbio/membrane.htm#Menu
This site is helpful because it allows you to select different concepts about
the cell membrane from a main menu. Each concept then includes a detailed but
concise summary and helpful diagrams and pictures. There is also a quiz included
to help you review the important ideas about the cell membrane along with an
overall summary. Overall Rating: 4
http://www.cbc.umn.edu/~mwd/cell_www/chapter2/membrane.html#PHOSPHOLIPIDS
This site is useful because it is well organized with headings about each of
the components of the cell membrane. Each component is explained briefly; therefore,
this site would be helpful for a quick, last minute review. Key terms and concepts
have links that let you view the definitions.
Overall Rating: 4
http://www.bact.wisc.edu/MicrotextBook/BacterialStructure/MembraneGen.html
We recommend this site because it contains straightforward explanations of concepts
accompanying bold, colorful images. However, this site concentrates on lipids
and barely mentions the function of the proteins in describing the lipid bilayer.
Definitions can be accessed for key terms via links.
Overall rating: 3
http://fhis.gcal.ac.uk/BIO/micro/drjrattray/cab1lec.summ/membranes.home.html
This site is helpful because it is organized well with detailed explanations
about the components of the cell membrane. However, this site does not have
colorful pictures to help the viewer visualize the concepts.
Overall Rating: 3
http://www.usd.edu/~bgoodman/Membrane.htm#figure
This site provides an attractive, colorful overview of the cell membrane but
only fully explains phospholipids and some of the functions of the cell membrane.
The information is too general, and the links for other cell membrane sites
do not work well.
Overall rating: 2
http://library.thinkquest.org/C004535/cell_membranes.html
This site provides a concise summary for a very basic understanding of the cell
membrane along with some good images. Even though lipids and phospholipids are
explained well, the site drifts away from detailed explanations about proteins
to types of transport. The site has an interesting feature called discuss
this topic that allows you to post questions about the cell membrane.
(Note: You must click Cellupedia, click here to view this site which
is in the middle of the web page.)
Overall rating: 2
http://esg-www.mit.edu:8001/cgi-bin/biosearch.pl?membranes
This
link brings you to all pages within the MIT hypertextbook which contan mention
to biological membranes.For the more
general link to the hypertextbook webpafe, followhttp://esg-www.mit.edu:8001/esgbio/7001main.html.The site is almost all text, but is interspersed
with helpful links which bring you to definitions of unknown words.
http://blanco.biomol.uci.edu/Bilayer_Struc.html
A
very good yet highly technical discussion of fluid lipid bilayers.If the high school textbook answer just doesn't
do it for you, come here for a much more detailed analysis of structure and
function.
http://cellbio.utmb.edu/cellbio/membrane.htm#Menu
This is a site full
of discussion on a variety of topics concerning cell membranes, from historical
perspective to surface specializations.While navigating the site is not as intuitive
as one may like, the vivid, informative graphics and plentiful information make
this site a useful resource providing a general overview of biological membranes.
http://www.jdaross.mcmail.com/cell2.htm
A good general overview of cellular membranes composed of phospholipid bilayers.
First section addresses the form and components of the membrane, including a
good drawing of a phospholipid. Second section addresses the Fluid Mosaic Model
and integral membrane proteins, with a diagram included. Also discusses the
semi-permeable property of membranes. The information is easy to understand,
save for a few grammar mistakes. Also, the author switches between using bilipid
layer and lipid bilayer, which can cause confusion.
Rating: 3
http://sun.menloschool.org/~cweaver/cells/c/cell_membrane/
Another general overview site. Very nice, professional diagrams, most likely
scanned from textbooks. Contains a little more information of the communication
functions of the membrane, including membrane receptors. Site is well-made and
neat, but doesnt contain heaps of information. Best used for its diagrams.
Rating: 3
http://www.omedon.co.uk/ionchan/
Complete with introduction and tabbed sections, this site offers a great explanation
of ion channels, and a limited but detailed description of plasma membranes
including chemical diagrams and colored images. Gives a reasonable explanation
for the transport of material across the membrane including how toxins manage
to fool the cell membrane. It also gives a listing of other websites
for further information. One downfall is the Potassium Protein illustration
does not seem to load well which is a weakness. Overall the site is very informative.
Rating: 4
http://www.bact.wisc.edu/MicroTextbook/BacterialStructure/Membranegen.html
This site gives you a little of everything. It begins with an overall outline
of the cell membrane, its components and structure. Great vibrant images animating
the parts of the cell membrane are available as well as multiple pages following
the first detailing more aspects of the plasma membrane. The site details the
different types of membrane proteins and the functions of a cell membrane. This
is a very well rounded site with lots of information. If you are looking for
a general overview of all aspects of the membrane it is fantastic, if looking
for detailed descriptions, it may lack a bit.
Rating: 4
http://cellbio.utmb.edu/cellbio/membran3.htm
This is an above average site with color-coded pictures about vocabulary such
as lipid bilayer, transmembrane proteins, microvilli, and unit membrane. These
vocab words link to another site that details information abou tthat specific
vocab word. Also has links to other sites with informaiton about membranes.
Rating: 5
http://home.earthlink.net/~dayvdanls/cell_membranes.htm
This site contains a large amount of other topics such as the fluid mosaic model,
passive and active transport, water potential, dialysis, osmosis, etc. Includes
chime images, 3D models, and labeled pictures of membranes, junctions, and diffusion
to name a few.
Rating: 5
Protein Synthesis
http://www.tusculum.edu/faculty/home/ivanlare/html/101/15.html#nul
We rate this a 3 out of 5 because it gives a good basic overview of the topic
but doesnt offer a complete explanation. A little juvenile, but it is
good for easy reference (mostly an outline).
http://wsrv.clas.virginia.edu/~rjh9u/trtrpict.html
We rate this web site a 4 out of 5 because it provides a visual aid and supplements
it with basic notes. Visually presents all of the steps of translation and clearly
displays all of the components involved.
http://wsrv.clas.virginia.edu/~rjh9u/gif/protein.mov
We rate this website a 5 out of 5 because it can be retrieved easily from the
Davidson Biology 111 website. The animation performs all of the actions involved
in protein synthesis. The site is completely visual and clear.
http://www.accessexcellence.org/AB/GG/protein_synthesis.html
We also give this website a 5 out of 5 because it, in a different way, thoroughly
demonstrates protein synthesis with images and brief definitions. The website
provides a good quick reference for easy vocabulary definitions and understanding.
http://tidepool.st.usm.edu/crswr/protsynthmov.html
We give this site a 4 out of 5 because it the most in depth of the sites, but
there seems to be too much going on to focus. Information wise, the website
engages the reader more, but the animation is not as pleasing to the eye.
http://www.indstate.edu/thcme/mwking/protein-synthesis.html
This is a very long site with very detailed info about Translation. Nothing
really on Transcription though, which is a little disappointing. It also come
from what looks like a reputable source( Indiana State)
http://tidepool.st.usm.edu/crswr/protsynthmov.html
This website has is very short but has a helpful animation about the processes
of Transcription and translation. Below the animation is a brief description
of what goes on. It also has a glossary of words that are highlighted and concept
that are not obvious.
http://web.jjay.cuny.edu/~acarpi/NSC/12-dna.htm
This website is not too intense but I like it because it seemed easy to
use and get a good overview of what we are looking for.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/A.html
This is the general index of this site, with almost every
technical bio term you could imagine - cool just in general, not just for our
topic. Again, provides many links between its pages where appropriate.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Transcription.html
This highly detailed site talks about transcription in DNA and RNA, providing
the steps, types of RNA, RNA polymerases, RNA processing (pre-mRNA and mRNA,
includes a diagram), split genes, and splicing. This site is very good with
links within its own pages (the Biology pages are immense) - most key terms
have their own link and are explained in more detail, often with illustrations.
There is an idex to each page at the top - very helpful. There are also links
to EM images.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Translation.html
Part of the previous site, this page details Translation from sequences of nucleotides
to RNA codons, the steps of translation (initiation, elongation, and termination:
with illustration), polysomes, and quality control (mutations, "errors",
decay, and their mechanisms). Both pages also have quick and easy summaries
at the bottom of the page.
http://www.eurekascience.com/ICanDoThat/protein_syn.htm
This site has very simple explanations and is in narrative style, aimed at younger
readers; therefore it is actually quite entertaining to read and provides a
good basic overview of the complicated process of protein synthesis. Obviously
its technical information is not as in depth as the other sites, but it is a
good beginner site with cool little moving animations.
http://www.accessexcellence.org/AB/GG/protein_synthesis.html
Cool diagram of protein synthesis and briefly describes (and shows location
of) transcription and translation: lots of info packed into this drawing. Leads
to a graphics gallery that could be quite helpful, in a myriad of cellular
topics:
http://www.accessexcellence.org/AB/GG/#Anchor-From-14210
http://gened.emc.maricopa.edu/bio/bio181/BIOBK/BioBookPROTSYn.html
This site gives a tremendous amount of information, including a bit of a history
lesson and numerous color scans of the process of protein synthesis. It's links
at the top provide a good general resource and the those at the bottom provide
even more specific information on protein synthesis.
http://www.ncc.gmu.edu/dna/ This site is a great general resource with brilliant animations hidden within the sections of the site.It's information is not very technical, but the step by step explanations of the process of synthesis is very helpful for visualization.
http://web.indstate.edu/thcme/mwking/protein-synthesis.html#interferon
-- Protein Synthesis.Although the layout of this
website is not particularly captivating -- it consists of a long page of text
with a navigation bar at the top functioning as a table of contents and is occasionally
infused with colorful graphics -- it contains a wealth of information about
the specific mechanisms of transcription and translation as well as regulation
mechanisms.Each individual step in the process -- from characterization of tRNAs
and amino acid activation to elongation and termination are described at length.Finally
at the end of the website, the different mechanisms of translation regulation
are described.The website explains regulation of translation by Heme, interferons,
iron and antibiotics.Overall, this website would be a good one to read for a
person interested in the regulation cascades of translation and in learning
the specific translation mechanisms.
http://tidepool.st.usm.edu/crswr/initiation.html
-- Initiation of Protein Synthesis
This
link points to an animation by a professor at the University of Southern Mississippi
illustrating the process of protein synthesis initiation.This animation is actually
a really good one, showing clearly the specific steps and processes involved
in translation.
http://ntri.tamuk.edu/cell/regulation.html
-- Regulation of Protein Synthesis
A
website maintained by the Natural Toxins Research Center at Texas A&M University
- Kingsville.This site contains an advanced genetic explanation of protein synthesis
regulation -- and is infused with helpful tables, graphics and figures that
make the topic interesting and the site easy to read.The site gives an advanced
explanation of transcriptional regulation in eukaryotes -- and explains current
protocols for studying this process, as well as an explanation and characterization
of the genes involved.The site explains regulation using steroid hormone receptors,
homeotic gene receptors, and cooperative regulation of the serum albumin gene.Overall
the site contains a well organized and interesting set of information regarding
regulation of protein synthesis -- and would be a good resource for a geneticist
looking for more advanced information or graphics regarding the subject.The
only problem with the site is that it contains no navigation bar nor an extensive
list of outside links to more information.
http://www.uga.edu/cellbio/FacultyPages/Keith.htm
Protein targeting
http://www.csus.edu/indiv/b/ballardr/Lecture%206%20-%20Protein%20Localization.doc
This is an online lecture for another college that provides a very good detailed
outline of the material, and summary questions for the students to make use
of. It also seems to make the class interactive with the discussion questions
as well. Score: 5
http://www.wikipedia.com/wiki/Protein_targeting
Good overall explanation of key terms of topic. It also provides links to terms
and definitions that users might find useful. Gives the general concept of the
topic and presents it in an easy way. Score 5
http://www.udallas.edu/biology/Ganter/molbio/proteinprocessing.html
This site provides a good outline for the topics. To learn the topic and be
able to recite the details of the small phrases provided most likely means you
understand the material well. Score: 3
http://www.upci.upmc.edu/internet/news/reuters/reuters.cfm?article=650
This site incorporates the topics like protein localization and shows how this
topic is applied in the real world. Current research processes are based upon
developments and techniques of this topic. Score: 3
http://www2.musc.edu/Pharm/sig_seq_review.pdf
This looks like an article from a science journal with specifics of the topic
for other researches to learn and use. It is very difficult to understand and
more for the use of advanced scientists. It is complete in structure, diagrams,
acknowledgements and citations. Score: 4
http://anx12.bio.uci.edu/~hudel/bs99a/lecture27/lecture8_2.html
http://www.islandone.org/Foresight/Conferences/MNT05/Papers/Wendel/
http://www.mun.ca/biochem/courses/3107/Lectures/Topics/Folding_etc.html
http://web.indstate.edu/thcme/mwking/protein-modifications.html
Other Links
http://www.biomed2.man.ac.uk/stirling/protein_targeting_to_the_endopla.htm
http://www.oup-usa.org/isbn/0199637415.html
http://fstgal12.tu-graz.ac.at:7777/pls/al12/ypl.detailinfo
http://bioresearch.ac.uk/browse/mesh/detail/C0887827L1772874.html
http://yakko.bme.virginia.edu/biom304/notes%5Cathero_sorting.htm
Intracellular trafficking (vesicular traffic)
http://rex.nci.nih.gov/RESEARCH/basic/lm/trafficking.htm
http://bioinfo.weizmann.ac.il/_ls/zvulun_elazar/zvulun_elazar.html
http://dir.nichd.nih.gov/cbmb/pb1labob.html
Cellular Scaffolding
http://www.uga.edu/cellbio/FacultyPages/Keith.htm
Dr. Bernd, this site was not part of my project but I found it and was intrigued
by it because it gives some information on a lab at the University of Georgia
that is busy studying cytoskeletal growth.This is a topic that no one in our
lab section was researching and I wasn't sure if anyone had found any information
for you regarding this topic.Anyway, it's just the homepage for a researcher
interested in this topic and has some pdf links to papers that are representative
of his work.
http://nessie.bch.ed.ac.uk/PAUL/ACTIN/
This site is an applet that allows you to create your own actin structure.
The instructions for the applet are straight forward and clear. Rating
3.75.
http://www.ks.uiuc.edu/Research/cell_motility/actin/
This sites has quicktime movies that show the primary and secondary structures
of the cell scaffolding. The Site is easy to browse and asthsticely pleasing.
Rating 4.00.
http://genome-www.stanford.edu/group/botlab/people/amberg/actin_images.html#BudSite
This is by far our most favorite site. There are movies to download that
cover the entire life time of yeast cells which show empahsis on the cell scaffolding.
Rating 5.00.
http://www.cytoskeleton.com/abactlg.htm
This is a basic overview of actin and the cytoskeleton. This is a good
site for a general information on cell scaffolding. Ratine 3.85.
http://www.itg.uiuc.edu/technology/atlas/structures/actin/
This is a one page site that shows stained pictures of the actin and microtubles
in a cell. Rating 3.00.
Molecular motors
http://physiology.med.uvm.edu/warshaw/
In the techniques section, there is animation next to a microscopic video image
of the technique. The candid photos of the researches gave it a personal touch.
Rating: 3.5
http://motility.york.ac.uk/
This site is very in depth with lots of links to other good sites. It also has
good images, animations, and even recordings of a myosin molecule.
Rating: 5
http://www.cse.ucsc.edu/~hongwang/ATP_synthase.html
This site has a good animation. Also, an in-depth image with labels of the parts
of an F1 molecular motor of ATP synthase. The description in this site is average
and the site has fewer links than others.
Rating: 3
http://mc11.mcri.ac.uk/ebiochem.html
The site has lengthy, detailed descriptions of the mechanisms of the motor and
the biochemistry of the motors. However, there are no images on this site.
Rating: 4
http://www.mih.unibas.ch/Booklet/Booklet96/Chapter2/Chapter2.html
This site shows a good research project. The images are well described, and
it ends with a good bibliography so you can find more information on molecular
motors.
Rating: 3.5
http://www.rpi.edu/locker/25/001225/public_html/nanowebprojects/jason/
This site has informative descriptions and animations of the muscle movement.
The site covers linear and rotational motor molecules. Many links to other related
topics and background information are included.
Rating: 5
http://motility.york.ac.uk/ Rating:
4.5
This is the web page of the Dept. of Molecular Motors at the University of York.,
which has links to a list labs working on molecular motors. The site also contains
many clear and exciting animations in color.
http://www.nhlbi.nih.gov/labs/molecularcardiology/motility.htm
Rating: 3
This is the National Heart, Lung and Blood Institutes website for their
Cellular and Molecular Motility Section. This link contains instructions and
illustrations of how to conduct a motility assay using actin and myosin. It
also contains a detailed, color, three-dimensional illustration of the surface
proteins and filaments and their interaction during the motility assay.
http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.html Rating: 4
This is from the Structural Classification of Proteins website. This is a hierarchy
of protein families containing three-dimensional Chime images of each protein,
not specifically motor proteins.
http://mc11.mcri.ac.uk/khome/index.html
Rating: 3
This is the kinesin homepage which contains links a movie page featuring animations
of many proteins as well as detailed descriptions and explanations the functions
and behaviors of different proteins.
http://www.sci.sdsu.edu/movies/actin_myosin.html
Rating: 5
A three-dimensional, high resolution animation of an actin myosin crossbridge
by the San Diego State University of the Sciences. We found this link at the
following website which contains a list of helpful links on Myosin, Motility,
Muscle and Cytoskeletal Groups a.k.a the Myosin People. (http://www.mrc-lmb.cam.ac.uk/myosin/muscleww.html)
Site #2: A University of Vermont research group devoted
to the study of molecular motors as they apply specifically to the actin-myosin
muscular complex.
http://physioweb.med.uvm.edu/Physioweb.php3?menu=Research
This site is a portion of the University of Vermont’s website that is devoted
to the research efforts of a group of professors. Each lab’s link contains an
abstract of that lab’s particular research goals and ideas. These interests
lie overwhelmingly with the study of myosin and how it relates to actin and
ATP on a molecular basis.The site also focuses on permutations of myosin type
and structure and how that relates to overall muscle function.The site contains
a little highly technical information about each research topic, but there is
enough background provided. Literature citations are included as well as animations
of various techniques for investigating myosin contraction.We ranked this site
as our second favorite.
Site #3: A cell diagram showing molecular motors.
http://faculty.plattsburgh.edu/donald.slish/Motors.html
This site, a portion of Professor
Donald Slish’s website at Plattsburg State University, contains a diagram of
a mitotic cell, which contains links to close-up animated views of molecular
motors contained thoughout the mitotic cell. Though not providing much in the
way of technical or even background information, the site provides an easily
explicable view of “why molecular motors are important.” The site made the list
simply because of its good use of applying molecular motors to the cell cycle
and by virtue of its cool animation. We rate it a 3.
Intracellular
signaling
WWW Virtual Library
of Cell Biology
www.vlib.org/Science/Cell_Biology/signal_transduction.shtml
This website
gives a host of other links to web pages for specific types of signal transduction.Some
examples include "The Learning Pathway: Cyclic AMP Second Messenger System"
and "Regulators of Signal Transduction Pathways." Probably a 5 because
it provides some great links.
Lecture Notes
at MIT
http://web.mit.edu/7.06/www/2001-Lectures/Lecture6/index.htm
These
are notes from a lecture at MIT entitled "Signaling: From the Cell Surface To
the Nucleus."The notes are in slide format
and include some great graphics.Excellent.This is a 5.The
notes are really helpful and are specific to the topic of intracellular signaling,
but there are other notes on this same site that would be helpful for other
topics.
Cell
Signaling Networks Database
http://geo.nihs.go.jp/csndb
This
is a good database of a number of signaling pathways that one can actually enter
a query to find.This ranks as a3
because once I started using it, it turned out not to have the specifics that
I was looking for.Not quite user-friendly.
The Yeast Pheromone
Signal Transduction Pathway
www.bri.nrc.ca/thomasweb/sigpath.htm
This
is a great graphic of this particular pathway.Clicking on any molecule in the picture also provides a brief description
of that molecule and its role in the pathway.5!And
pertains to our lab.
http://www.ascb.org/news/vol24no4
(After accessing this directory,
click on the April-01 pdf file link.)
This
article is about Jennifer Lippincott-Schwartz, specifically about her decision
to become a cell biologist and to research intracellular trafficking.Rating: 4
http://www.mpi-dortmund.mpg.de/departments/dep2/kipp/rechts1.php3
This
site is another research abstract from a group of German biologists that are
studying intracellular trafficking in epithelial cells.The
article is quite detailed, but includes good descriptions of how trafficking
operates and is regulated. Rating: 3
Extracellular
communication
Cell Biology.com: Cellular Communication- 5
http://www.cell-biology.com/cellcom.html
This general overview of intercellular communication discusses the various forms
of communication (endocrine, paracrine, etc.) and the types of receptors and
receptor mechanisms used to transmit these extracellular signals into a change
in function for a cell. Within the text of the page are links to useful pages
on related topics.
Cell Signaling Pathway Slides- 4
http://www.sial.com/Area_of_Interest/Life_Science/Cell_Signaling/Pathway_Slides_and_Charts.html
This website contains links to pages with diagrams and text relevant to many
processes in cell biology (apoptosis, cell cycle, gene expression regulation,
etc.) that are controlled by both intercellular and intracellular signaling.
The slide Cytokines, Growth Factors, and Hormones contains information
more specifically relevant to intercellular communication.
Journal of Neuroscience:
Control and Plasticity of Intercellular Calcium Waves in Astrocytes: A Modeling
Approach- 2
http://www.jneurosci.org/cgi/content/full/22/12/4850
From the Journal of Neuroscience online, this article gives a technical discussion
of a specific form of intercellular signaling. Despite its specificity, the
article also discusses general methods of intercellular signaling like transmission
across gap junctions and through extracellular space. It discusses the complexity
of the control networks required for effective communication between cells.
Intercellular Communication- 1
http://www2.mrc-lmb.cam.ac.uk/pandfpages/pfic.html
The beginning paragraph of this site is a good general definition of intercellular
communication. The site also provides specific examples of intercellular and
intracellular communication and other chemosensory examples from organisms like
Drosophila. The information is very general.
Cell to Cell Signaling- 4
http://www.shsu.edu/~bio_bls/signal.htm
This site contains an in-depth outline covering the mechanisms involved and
chemicals used in intercellular communication. The site contains clear definitions
of the major types of intercellular signaling and detailed information about
specific signaling molecules.
Introduction to Hormones and other Signaling Molecules and their Receptors-
5
http://web.mit.edu/7.06/www/2001-Lectures/Lecture5/sld001.htm
This site contains a slide show in which slides 1 through 6 deal with intercellular
signaling. There are good diagrams of the types of intercellular signaling such
as signaling by membrane attached proteins, as well as autocrine, paracrine,
and endocrine signaling.
http://lifesci.rutgers.edu/~fong/15.htm
This
website gives a general overview of the mechanisms and molecules involved in
extracellular communication, with specific emphasis on signal transduction pathways.It
has a lot of information with keywords and phrases highlighted for emphasis.
http://www.shsu.edu/~bio_bls/signal.htm
This
link provides another overview of cell-to-cell communication mechanisms.The page covers types of signalers, receptors,
and pathways involved in the many varieties of cellular communication.
http://www.vacadsci.org/PUB/chap41.pdf
This
website outlines the chemical signals used in intracellular communication.It deals mostly with the glands that produce
the signals and the signals themselves.Although is does not focus on the details of the pathways, it gives
a thorough description of the general processes that are occurring during extracellular
communication.
http://www.whatislife.com/reader2/chapter_summary.htm
<http://www.nysaes.cornell.edu/fst/faculty/acree/pheronet/pherom.html
This
site offers general summary of cell membrane transport and signaling.Gives links to the principles and applications
of the components of the cell membrane.
http://www.sci.sdsu.edu/classes/bio366/TFrey/CellSignal1/sld002.htm
This
site gives a pictorial representation of three general types of extracellular
signaling.It aids in the visualization
of the processes.
Protein Degradation
http://www.neuro.wustl.edu/neuromuscular/mother/degrade.htm
A convenient outline with links to extra sites about key words, this site includes detailed
explanatory pictures and examples of proteins. It also outlines the steps
in the degradation process. It's easy to read; we rate it an excellent:
5.
http://vlib.org/Science/Cell_Biology/proteins.shtml
This site is primarily an extensive list of both general and topic-specific
links to other sites. The links contain a broad range of information,
with introductory and detailed explanations of protein degradation.
There are also some links to discussion groups. We give this site
a very good: 4.
http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb2/part1/protease.htm
This site is a general overview with color coded key words, definitions, and a
few helpful pictures, though mostly writing. It contains details on ubiquitin
and various proteases and can also be viewed as slide show. It would
be good for basic research; we give it a very good: 4.
http://www.mol.biol.ethz.ch/praktikum/lecture2.pdf
This site is a very detailed powerpoint presentation with lots of detailed pictures
and extensive information on ubiquitin and proteasomes. We give it
an excellent: .5
http://www.aecom.yu.edu/cuervo/aging_and_protein_degradation.htm
This site draws a connection between aging and protein degradation.
It's a general overview page with links to more detailed sites about aging,
protein degradation, lysosomes, and mediated autophagy. We rate it a good: 3.
http://depts.washington.edu/sfields/yplm/data/DegWallRnaprocMat.pdf
This is that picture of the network of interacting yeast proteins.
Cell Cycle
http://www.biology.arizona.edu/cell_bio/tutorials/cell_cycle/main.html
This site was a concise and easy to navigate tutorial. It is presented in outline
format and clearly describes each cell stage. There are vocabulary links to
further explain each event in the cell cycle, as well as having pictures and
diagrams.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/CellCycle.html
This site was presented in outline format with no paragraphs. In text links
offer more in depth information without hindering a general overview of the
cell cycle. It is easy to find specific details through links.
http://www.cellsalive.com/cell_cycle.htm
This site was easy to read and had good visuals with animation. It did not contain
as much information as the first site, because the information was even more
concise. The site was colorful and offered links to do searches for more detailed
information.
http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/cellcycle/cellcycl1.htm
An alternative diagram to the cell cycle is presented here. Detailed specifics
on proteins are offered, and the site is designed to explain the cell cycle
in terms of cancer. There are some useful definitions and links to other detailed
topics, such as cancer.
http://www.geocities.com/CollegePark/Lab/1580/cycle.html
Here you will find good basic information. The site is harder to read
due to its busy background. It is presented in a type of outline, with paragraphs
as well. It took longer to read than the other sites.
http://www.people.virginia.edu/~rjh9u/cdk.html
"Cell Cycle Control Points
and Cancer" depicts and describes the cell cycle phases as well as the function
and mechanism of cell cycle checkpoints; it also describes how mutant genes,
when capable of removing or effecting a checkpoint or transcription inhibitor,
can lead to tumor development. Diagrams of the cell cycle and the effect
that mutations have on it are provided, as well as links to cell cycle control
in the yeast Schizosaccharomyces pombe.
Apoptosis
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/Apoptosis.html
This website is a detailed outline explaining what apoptosis is how cells
die (injury or suicide programmed cell death), why cells goes through
apoptosis, the mechanisms of apoptosis. It has two great diagrams (of how apoptosis
occurs with an external signal and how apoptosis occurs with a target recognition
system) and gives examples of diseases in which apoptosis occurs.
Grade 5
http://www.cellsalive.com/apop.htm
While containing an amusing animation, this website is not very helpful. It
mentions the role of apoptosis in the immune system pertaining to neutrophils.
Grade 1
http://sdb.bio.purdue.edu/fly/vdevlhom/pdeath.htm
This site contains a great definition of apoptosis and introduces the term PCD
programmed cell death. It also contains a list of genes responsible for
apoptosis in Drosophila and their homologues in mammals.
Grade 4
http://www.geocities.com/CollegePark/Lab/1580/apoptosis.html
This site contains a very good introduction to apoptosis. It gives an example
of where apoptosis did not occur in polydactyly making it interesting
to students. Later down the page it includes a small diagram of a cell-signaling
pathway of apoptosis.
http://www.geocities.com/j_robens/apoptosis.html
This site gives information with a developmental biology perspective and gives
a detailed explanation of apoptosis. Some of the points of interest on this
website include thorough information regarding the role of the specific genes
that are involved in apoptosis, the cell cycle, the difference between necrosis
and apoptosis and many others.This site has clear diagrams and gives examples
of good model systems.Rating-4.
http://www.naturesj.com/cdd/
This web site is the home page for the Cell Death and Differentiation
Journal.It is a highly technical site focused on searching the journal for articles
on specific topics relating to programmed cell death and apoptosis.Rating-4.
http://www.celldeath.de/mainfram.htm
Contains glossary, protocols, list of labs working in the field
of apoptosis, a forum, and good links to other apoptosis websites including
the link below.
http://www.medicine.uiowa.edu/pathology/path%5Ffolder/faculty/knudson/knudson.html
This
link is to the homepage of a University of Iowa M.D., Ph.D.’s page and it includes
links to his lectures on apoptosis which are very easy to follow and have good
graphics including sample data from his research.This
link would be helpful as a general resource for those interested in learning
more about apoptosis.It’s not too technical,
but some understanding of biology would be useful. Rating-4.