LOCUS       NM_002654    2287 bp    mRNA            PRI       19-MAR-1999
     DEFINITION  Homo sapiens pyruvate kinase, muscle (PKM2) mRNA.
     ACCESSION   NM_002654
     VERSION     NM_002654.1  GI:4505838
     KEYWORDS    .
     SOURCE      human.
       ORGANISM  Homo sapiens
                 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
                 Eutheria; Primates; Catarrhini; Hominidae; Homo.
     REFERENCE   1  (bases 1 to 2287)
       AUTHORS   Tani,K., Yoshida,M.C., Satoh,H., Mitamura,K., Noguchi,T.,
                 Tanaka,T., Fujii,H. and Miwa,S.
       TITLE     Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment
                 and expression in hepatoma
       JOURNAL   Gene 73, 509-516 (1988)
       MEDLINE   89211988
     COMMENT     REFSEQ: This reference sequence was derived from M23725.
                 Draft entry and computer-readable sequence for [1] kindly provided
                 by K.Tani, 04-APR-1989.
                 PROVISIONAL RefSeq: This is a provisional reference sequence record
                 that has not yet been subject to human review. The final curated
                 reference sequence record may be somewhat different from this one.
     FEATURES             Location/Qualifiers
          source          1..2287
                          /organism="Homo sapiens"
                          /db_xref="taxon:9606"
                          /tissue_type="liver"
          gene            1..2287
                          /gene="PKM2"
                          /note="PK3"
                          /db_xref="LocusID:5315"
                          /db_xref="MIM:179050"
          CDS             110..1705
                          /gene="PKM2"
                          /EC_number="2.7.1.40"
                          /codon_start=1
                          /db_xref="LocusID:5315"
                          /db_xref="MIM:179050"
                          /product="pyruvate kinase, muscle"
                          /protein_id="NP_002645.1"
                          /db_xref="GI:4505839"
                          /translation="MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARN
                          TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDP
                          ILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLD
                          YKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDL
                          PAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEG
                          VRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESM
                          IKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQNLIAREAEAAIYHL
                          QLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPI
                          IAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDV
                          VIVLTGWRPGSGFTNTMRVVPVP"
     BASE COUNT      501 a    648 c    654 g    484 t
     ORIGIN
             1 ggctgaggca gtggctcctt gcacagcagc tgcacgcgcc gtggctccgg atcttcttcg
            61 tctttgcagc gtagcccgag tcggtcagcg ccagaggacc tcagcagcca tgtcgaagcc
           121 ccatagtgaa gccgggactg ccttcattca gacccagcag ctgcacgcag ccatggctga
           181 cacattcctg gagcacatgt gccgcctgga cattgattca ccacccatca cagcccggaa
           241 cactggcatc atctgtacca ttggcccagc ttcccgatca gtggagacgt tgaaggagat
           301 gattaagtct ggaatgaatg tggctcgtct gaacttctct catggaactc atgagtacca
           361 tgcggagacc atcaagaatg tgcgcacagc cacggaaagc tttgcttctg accccatcct
           421 ctaccggccc gttgctgtgg ctctagacac taaaggacct gagatccgaa ctgggctcat
           481 caagggcagc ggcactgcag aggtggagct gaagaaggga gccactctca aaatcacgct
           541 ggataacgcc tacatggaaa agtgtgacga gaacatcctg tggctggact acaagaacat
           601 ctgcaaggtg gtggaagtgg gcagcaagat ctacgtggat gatgggctta tttctctcca
           661 ggtgaagcag aaaggtgccg acttcctggt gacggaggtg gaaaatggtg gctccttggg
           721 cagcaagaag ggtgtgaacc ttcctggggc tgctgtggac ttgcctgctg tgtcggagaa
           781 ggacatccag gatctgaagt ttggggtcga gcaggatgtt gatatggtgt ttgcgtcatt
           841 catccgcaag gcatctgatg tccatgaagt taggaaggtc ctgggagaga agggaaagaa
           901 catcaagatt atcagcaaaa tcgagaatca tgagggggtt cggaggtttg atgaaatcct
           961 ggaggccagt gatgggatca tggtggctcg tggtgatcta ggcattgaga ttcctgcaga
          1021 gaaggtcttc cttgctcaga agatgatgat tggacggtgc aaccgagctg ggaagcctgt
          1081 catctgtgct actcagatgc tggagagcat gatcaagaag ccccgcccca ctcgggctga
          1141 aggcagtgat gtggccaatg cagtcctgga tggagccgac tgcatcatgc tgtctggaga
          1201 aacagccaaa ggggactatc ctctggaggc tgtgcgcatg cagaacctga ttgcccgtga
          1261 ggcagaggct gccatctacc acttgcaatt atttgaggaa ctccgccgcc tggcgcccat
          1321 taccagcgac cccacagaag ccaccgccgt gggtgccgtg gaggcctcct tcaagtgctg
          1381 cagtggggcc ataatcgtcc tcaccaagtc tggcaggtct gctcaccagg tggccagata
          1441 ccgcccacgt gcccccatca ttgctgtgac ccggaatccc cagacagctc gtcaggccca
          1501 cctgtaccgt ggcatcttcc ctgtgctgtg caaggaccca gtccaggagg cctgggctga
          1561 ggacgtggac ctccgggtga actttgccat gaatgttggc aaggcccgag gcttcttcaa
          1621 gaagggagat gtggtcattg tgctgaccgg atggcgccct ggctccggct tcaccaacac
          1681 catgcgtgtt gttcctgtgc cgtgatggac cccagagccc ctcctccagc ccctgtccca
          1741 cccccttccc ccagcccatc cattaggcca gcaacgcttg tagaactcac tctgggctgt
          1801 aacgtggcac tggtaggttg ggacaccagg gaagaagatc aacgcctcac tgaaacatgg
          1861 ctgtgtttgc agcctgctct agtgggacag cccagagcct ggctgcccca tcatgtggcc
          1921 ccacccaatc aagggaagaa ggaggaatgc tggactggag gcccctggag ccagatggca
          1981 agagggtgac agcttccttt cctgtgtgta ctctgtccag ttcctttaga aaaaatggat
          2041 gcccagagga ctcccaaccc tggcttgggg tcaagaaaca gccagcaaga gttaggggcc
          2101 ttagggcact gggctgttgt tccattgaag ccgactctgg ccctggccct tacttgcttc
          2161 tctagctctc taggcctctc cagtttgcac ctgtccccac cctccactca gctgtcctgc
          2221 agcaaacact ccaccctcca ccttccattt tcccccacta ctgcagcacc tccaggcctg
          2281 ttgccgc
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