Human Genome Module

Background Information

What were the goals of the Human Genome Initiative?

How is DNA sequenced?

Images of DNA sequencing

Is every base important? (human gender paper)

Is every base important? (sickle cell activity)

Compare ATP, dATP and ddATP structures (Jmol display of 3D structures)

 

Database Activities

Genome Browser (UCSC)

CFTR (cystic fibrosis)

Syntrophin

BLAST

HD (Huntington's Disease)

Bacterial Gene Hunt

OMIM

Fava Bean

Transferrin

Whole Genome Comparisons (TIGR)

Compare two E. coli strains

M. genetalium

SNP Database (NCBI)

Explore SNP database

HapMap Search for SNPs

Assessment - very challenging

Testing

Sample Tests

One Exam with answers

Second Exam with answers

Reference: Campbell, A. M. Public Access for Teaching Genomics, Proteomics, and Bioinformatics. Cell Biology Education. 2003. Vol. 2: 98- 111.

Web Page Assignments

1) scientific v. popular press

2) YFYG sequences (linked known & unknown; YFYG = Your Favorite Yeast Gene)

3) YFYG expression data

Sample Student Pages

How to make web pages

References

• A. Malcolm Campbell and Laurie J. Heyer. Discovering Genomics, Proteomics & Bioinformatics. Published jointly by Cold Spring Harbor Laboratory Press and Benjamin Cummings. 352 pages. ISBN 0-8053-4722-4
• A. Malcolm. Campbell. 2002. Instructor’s Guide to “Discovering Genomics, Proteomics & Bioinformatics”. Benjamin Cummings. 136 pages. ISBN: 0805347267
• Campbell, A. M. Open Access: A PLoS for Education. PLoS Biology. 2004. Vol. 2 (5): 560-563. (PDF Version)
• Campbell, A. M. Public Access for Teaching Genomics, Proteomics, and Bioinformatics. Cell Biology Education. 2003. Vol. 2: 98- 111.
• Campbell, A. M. Meeting Report: Genomics in the Undergraduate Curriculum-Rocket Science or Basic Science? Cell Biology Education. 2002. Vol. 1: 70 - 72.

© Copyright 2005. Malcolm Campbell. Department of Biology, Davidson College, Davidson, NC 28035
Send comments, questions, and suggestions to: macampbell@davidson.edu