Immunology Reading Schedule Spring 2000 - Davidson College Biology Dept.

Week	Sections	Notes or Comments
Jan. 19 - 21
W	Introduction and Entrance Exam	Immunology Main Page
F	1.1 - 1.11	HHH - cell types HHH- bone marrow HHH- thymus HHH- lymph node HHH- spleen macrophage eating a pathogen Chime view of Antibody Fab fragment with bound antigen (lysozyme)
Jan. 24 - 28
M	1.12 - 2.13	Tc killing infected cell - QT movie ELISA method - QT movie Antibody avidity - QT movie Immunofluorescence methodology Western Blot Figure image only
W	2.14 - 2.27	FACS machine RT-PCR - Flash animiation loxP paper (restricted access)
F	3.1 - 3.15	Chime view of Antibody Fab fragment with bound antigen (lysozyme) Somatic Recombination - Flash Animation Chime view of dsDNA (for 12/23 rule) Chime view of DNA-binding protein
Jan. 31 - Feb. 4
M	3.16 - 3.24	Somatic Recombination - Flash Animation Chime view of DNA-binding protein
W	4.1 - 4.14	Chime of MHCI (select Class I MHC) Chime of MHCII (select Class II MHC) Loading peptide in MHCI - Flash Animation Loading peptide in MHCII - Flash Animation
F	4.15 - 4.22	Chime of MHCI (select Class I MHC) Chime of MHCII (select Class II MHC) Somatic Recombination - Flash Animation HLA-G - written by Kelly Carter '00
Feb. 7 - 11
M	4.23 - 4.30	Murine T-Cell Receptor Human TCR + HLA-A2 + HTLV-1 Peptide Human MHCIi HLA-Dr1 & Bacterial Superantigen Seb TCR b Chain+ Sec3 Superantigen Staphylococcal Enterotoxin Toxic Shock Syndrome Toxin-1 Staphylococcal Enterotoxin C2 CD8 (N-Terminal 114 Residues) CD4 (D1D2 Fragment) CD4 (D1-D4 and dimerized) Complex Of The Human MHCI HLA-A2 & CD8 Thymus Histology (site of TCR gene recombination)
W	Clinical Day #1	(End of First Exam Material)
F	Review Session and First Exam Distributed
Feb. 14 - 18
M	First Exam Due	WWW workshop Web Standards for this course How to create web pages A template for your use How to find a Chime File of YFIP How to embed a Chime file in your web page How to load your pages onto the BioServer How to create relative links How to make Greek letters in html
W	5.1 - 5.10	(Begin Second Exam Material) TI B cell activation - Flash animation IP₃ signal transduction - Flash animation Lck - written by Emily Lampp '00 MAPK pathway - Flash animation (by Dr. Vic Lemas)
F	5.11 - 5.20	IP₃ signal transduction - Flash animation NFAT - written by Tim Deeb '00 NFAT structure - Chime image shown with DNA MAPK pathway - Flash animation (by Dr. Vic Lemas) JAK3 - written by Charles Haines '00 Quick Lesson on Apoptosis induced DNA fragments
Feb. 21 - 25
M	6.1 - 6.6	B Cell Development - Flash animation
W	6.7 - 6.12	HHH - cell types HHH of spleen HHH of lymph node B cell Selection - Flash Animation
F	6.13 - 6.16	HHH of spleen HHH of lymph node HHH- bone marrow Karyotype of translocation - see Philadelphia Chromosome Chromosomal information about bcl-2
Feb. 28 - Mar. 3
M	7.1 - 7.5	HHH- thymus T Cell Selection- Flash animation (by Dr. Vic Lemas)
W	7.6 - 7.11	HHH- thymus Somatic Recombination - Flash Animation T Cell Selection- Flash animation (by Dr. Vic Lemas)
F	7.12 - 7.21 (End of Second Exam Material)	HHH- thymus T Cell Selection- Flash animation (by Dr. Vic Lemas) Home Page on YFIP Due by noon
March 6 - 10
M W F	Spring Break!!
March 13 - 17
M	8.1 - 8.13	(Begin Third Exam Material) HHH - Hyperlinked Human Histology Signal Transduction (Review Animations Below) IP3 Pathway MAPK Pathway
W	Clinical Day #2	Common g chain and JAK3 - by Charles Haines '00
F	Review Session	Second Exam Distributed
March 20 - 24
M	Second Exam Due	Plus Web & Term Paper Help
W	8.14 - 8.22	Apoptosis Pathway Apoptosis cleavage of DNA Apoptosis web Resources Exocytosis Figure Tc killing its target - QT Movie IP3 Pathway
F	8.23 - 8.28	Cytokines: - IFN-g by Dax Allred '00; and Meredith Gramer '00 - IFN-b by Will White '00 - Lymphotoxin by Brenda Bondesen '00 - TNF - a by Rachel Wolf '00 - IL- 7 by Melanie Majure '00 - IL- 10 by Stacey Spolnik '01 - IL - 12 by Brent Wilson '00 Chemokine Families Leishmania - Clinical Leishmania - Immunity Leishmania - Evading Destruction Leishmania - Treatment Interesting Approach to Learing about Listeria Listeria - symptoms and treatment
March 27 - 31
F	9.1 - 9.10	TI B cell activation - Flash animation HHH - Germinal Center
W	9.11 - 9.21	Eosinophils - HHH images Histamine - by David Lamar '01 Bacteria Bacterial Pathogens Triggers Endocytosis - EM image Animations of infection - by Brett Finlay and HHMI Salmonella enducing apoptosis Salmonella living inside macrophages Salmonella and "organic foods" Salmonella Fact Sheet Helminths Ascaris lumbricoides - from CDC web site on parasites and diagnosis Hookworm - from CDC web site on parasites and diagnosis Protozoan Leishmania - from CDC web site on parasites and diagnosis
F	9.22 - 9.31 (skim complement) plus 10.1 - 10.5	Complement Cascade - by Jason Dyer TI B cell activation (note complement receptors) Alzheimer's, Down's Syndrome and Complement
April 3 - 7
M	10.6 - 10.15	Oxidative Burst IFN-b - by Will White '00 HIV binding chemokine receptors - Flash animation by Hoffmann-La Roche
W	10.16 - 10.29	Hyperlinked Human Histology Chemokines in Homing Tissue Distribution of Chemokines (End of Third Exam Material)
F	Review Session	Third Exam Distributed
April 10 - 14
M	Third Exam Due	More help with WWW and Papers
W	11.1 - 11.13	Plasmodium Images - by CDC Animations of infection - by Brett Finlay and HHMI TI activation of B cell B Cell Development Complement Cascade MHC II peptide loading MHC I peptide loading IL-2 gc Receptor
F	11.14 - 11.25	WHO stats on AIDS (1997) HIV binding chemokine receptors - Flash animation by Hoffmann-La Roche
April 17 - 21
M	Clinical Day #3	Eye Movement Problems
W	12.1 - 12.9	HHH - eosinophils histamine - by David Lamar '01
F	12.10 - 12.18	Penicillin G structure (b-lactam ring with 3C and 1N) ELISA method - QT movie Paper Must be Posted by Noon
April 24 - 28
M	Easter Break
W	13.1 - 13.13	Chime of MHCII (select Class II MHC) Loading peptide in MHCII - Flash Animation Autoimmune Diseases: restricted - campus only Sjogren's Syndrome Heather Baker '00 Goodpasture's Syndrome Kelly Carter '00 Lupus (SLE) Karen Fritchie '00 & Brent Wilson '00 nucleosome structure Diabetes - Scott Hutchins '00 and Stacy Spolnik '01 and Jonathon Weed '00 Myasthenia Gravis Jennifer Starr '00 Osteoarthritis Al Vichot '01 Hemolytic Anemia Rachel Wolf '00 Multiple Sclerosis Erin Woodall '00 and Melanie Majure '00
F	13.14 - 13.29	HLA-G - by Kelly Carter '00
May 1 - 5
M	14.1 - 14.10	Information about NFAT - by Tim Deeb '00 NF-AT structure - Chime image shown with DNA
W	14.11 - 14.15 plus news stories	Images of Tumors
F	14.16 - 14.28	Gene Gun for DNA vaccines Chemokines to Block HIV Infections?
May 8 - 10
M	Clinical Day #4	Eye Movement Problems (End of Final Exam Material)
W	Slide Show + Review Session	Fourth Exam Distributed
F	Final Exam Due 5 pm	Grading starts promptly at 5:01 pm!

Immunology - Spring 2000

Dr. A. Malcolm Campbell

Dana 221 phone: x2692 email: macampbell

office hours: M, 2-3:30 and Tues. 10 - 11:30 plus open door policy